Cargando…
Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery
The optimal alternative anticoagulation regimen for patients with heparin-induced thrombocytopenia (HIT) who need surgical procedures that involve higher levels of anticoagulation, usually performed under heparin, is not yet established. Argatroban has been reported as a safe alternative. Plasma lev...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701080/ https://www.ncbi.nlm.nih.gov/pubmed/36447732 http://dx.doi.org/10.7759/cureus.30763 |
_version_ | 1784839465131311104 |
---|---|
author | Nogueira, Sara Queijo, Joana Teles, Ana Rita |
author_facet | Nogueira, Sara Queijo, Joana Teles, Ana Rita |
author_sort | Nogueira, Sara |
collection | PubMed |
description | The optimal alternative anticoagulation regimen for patients with heparin-induced thrombocytopenia (HIT) who need surgical procedures that involve higher levels of anticoagulation, usually performed under heparin, is not yet established. Argatroban has been reported as a safe alternative. Plasma levels and their anticoagulant effects follow a predictable profile. Also, it is easily monitored and its pharmacokinetic profile makes it suitable for patients with renal failure, as it undergoes hepatic elimination. However, its use as a substitute for heparin in HIT patients is not well-documented, especially in vascular surgery. We present a case of a successfully managed patient with acute HIT undergoing limb vascular surgery using anticoagulation with argatroban. |
format | Online Article Text |
id | pubmed-9701080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-97010802022-11-28 Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery Nogueira, Sara Queijo, Joana Teles, Ana Rita Cureus Anesthesiology The optimal alternative anticoagulation regimen for patients with heparin-induced thrombocytopenia (HIT) who need surgical procedures that involve higher levels of anticoagulation, usually performed under heparin, is not yet established. Argatroban has been reported as a safe alternative. Plasma levels and their anticoagulant effects follow a predictable profile. Also, it is easily monitored and its pharmacokinetic profile makes it suitable for patients with renal failure, as it undergoes hepatic elimination. However, its use as a substitute for heparin in HIT patients is not well-documented, especially in vascular surgery. We present a case of a successfully managed patient with acute HIT undergoing limb vascular surgery using anticoagulation with argatroban. Cureus 2022-10-27 /pmc/articles/PMC9701080/ /pubmed/36447732 http://dx.doi.org/10.7759/cureus.30763 Text en Copyright © 2022, Nogueira et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Anesthesiology Nogueira, Sara Queijo, Joana Teles, Ana Rita Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery |
title | Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery |
title_full | Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery |
title_fullStr | Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery |
title_full_unstemmed | Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery |
title_short | Recent Myocardial Infarction and Acute Heparin-Induced Thrombocytopenia: A Case Report on Perioperative Management of a Patient for Acute Limb Vascular Surgery |
title_sort | recent myocardial infarction and acute heparin-induced thrombocytopenia: a case report on perioperative management of a patient for acute limb vascular surgery |
topic | Anesthesiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701080/ https://www.ncbi.nlm.nih.gov/pubmed/36447732 http://dx.doi.org/10.7759/cureus.30763 |
work_keys_str_mv | AT nogueirasara recentmyocardialinfarctionandacuteheparininducedthrombocytopeniaacasereportonperioperativemanagementofapatientforacutelimbvascularsurgery AT queijojoana recentmyocardialinfarctionandacuteheparininducedthrombocytopeniaacasereportonperioperativemanagementofapatientforacutelimbvascularsurgery AT telesanarita recentmyocardialinfarctionandacuteheparininducedthrombocytopeniaacasereportonperioperativemanagementofapatientforacutelimbvascularsurgery |