Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect

Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade of the ‘don’t-eat-me’ cell-surface molecule CD47 in small cell lung cancer (SCLC), a highly metastatic form of lung cancer. CD47 blockade potently enh...

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Detalles Bibliográficos
Autores principales: Nishiga, Yoko, Drainas, Alexandros P., Baron, Maya, Bhattacharya, Debadrita, Barkal, Amira A., Ahrari, Yasaman, Mancusi, Rebecca, Ross, Jason B., Takahashi, Nobuyuki, Thomas, Anish, Diehn, Maximilian, Weissman, Irving L., Graves, Edward E., Sage, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701141/
https://www.ncbi.nlm.nih.gov/pubmed/36411318
http://dx.doi.org/10.1038/s43018-022-00456-0

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