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Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018

Enterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the introduction of the EV-A71 vaccine into the National Immunization Programme, we investigated the seroepidemiological characteristics of EV-A...

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Autores principales: Yang, Juan, Liao, Qiaohong, Luo, Kaiwei, Liu, Fengfeng, Zhou, Yonghong, Zou, Gang, Huang, Wei, Yu, Shuanbao, Wei, Xianglin, Zhou, Jiaxin, Dai, Bingbing, Qiu, Qi, Altmeyer, Ralf, Hu, Hongan, Paireau, Juliette, Luo, Li, Gao, Lidong, Nikolay, Birgit, Hu, Shixiong, Xing, Weijia, Wu, Peng, van Doorn, H. Rogier, Horby, Peter W., Simmonds, Peter, Leung, Gabriel M., Cowling, Benjamin J., Cauchemez, Simon, Yu, Hongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701185/
https://www.ncbi.nlm.nih.gov/pubmed/36435844
http://dx.doi.org/10.1038/s41467-022-34992-1
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author Yang, Juan
Liao, Qiaohong
Luo, Kaiwei
Liu, Fengfeng
Zhou, Yonghong
Zou, Gang
Huang, Wei
Yu, Shuanbao
Wei, Xianglin
Zhou, Jiaxin
Dai, Bingbing
Qiu, Qi
Altmeyer, Ralf
Hu, Hongan
Paireau, Juliette
Luo, Li
Gao, Lidong
Nikolay, Birgit
Hu, Shixiong
Xing, Weijia
Wu, Peng
van Doorn, H. Rogier
Horby, Peter W.
Simmonds, Peter
Leung, Gabriel M.
Cowling, Benjamin J.
Cauchemez, Simon
Yu, Hongjie
author_facet Yang, Juan
Liao, Qiaohong
Luo, Kaiwei
Liu, Fengfeng
Zhou, Yonghong
Zou, Gang
Huang, Wei
Yu, Shuanbao
Wei, Xianglin
Zhou, Jiaxin
Dai, Bingbing
Qiu, Qi
Altmeyer, Ralf
Hu, Hongan
Paireau, Juliette
Luo, Li
Gao, Lidong
Nikolay, Birgit
Hu, Shixiong
Xing, Weijia
Wu, Peng
van Doorn, H. Rogier
Horby, Peter W.
Simmonds, Peter
Leung, Gabriel M.
Cowling, Benjamin J.
Cauchemez, Simon
Yu, Hongjie
author_sort Yang, Juan
collection PubMed
description Enterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the introduction of the EV-A71 vaccine into the National Immunization Programme, we investigated the seroepidemiological characteristics of EV-A71 in two prospective cohorts of children in southern China conducted between 2013 and 2018. Our results show that maternal antibody titres declined rapidly in neonates, with over half becoming susceptible to EV-A71 at 1 month of age. Between 6 months and 2 years of age, over 80% of study participants were susceptible, while one third remained susceptible at 5 years old. The highest incidence of EV-A71 infections was observed in children aged 5-6 months. Our findings support EV-A71 vaccination before 6 months for birth cohorts in southern China, potentially with a one-time catch-up vaccination for children 6 months-5 years old. More regionally representative longitudinal seroepidemiological studies are needed to further validate these findings.
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spelling pubmed-97011852022-11-28 Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018 Yang, Juan Liao, Qiaohong Luo, Kaiwei Liu, Fengfeng Zhou, Yonghong Zou, Gang Huang, Wei Yu, Shuanbao Wei, Xianglin Zhou, Jiaxin Dai, Bingbing Qiu, Qi Altmeyer, Ralf Hu, Hongan Paireau, Juliette Luo, Li Gao, Lidong Nikolay, Birgit Hu, Shixiong Xing, Weijia Wu, Peng van Doorn, H. Rogier Horby, Peter W. Simmonds, Peter Leung, Gabriel M. Cowling, Benjamin J. Cauchemez, Simon Yu, Hongjie Nat Commun Article Enterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the introduction of the EV-A71 vaccine into the National Immunization Programme, we investigated the seroepidemiological characteristics of EV-A71 in two prospective cohorts of children in southern China conducted between 2013 and 2018. Our results show that maternal antibody titres declined rapidly in neonates, with over half becoming susceptible to EV-A71 at 1 month of age. Between 6 months and 2 years of age, over 80% of study participants were susceptible, while one third remained susceptible at 5 years old. The highest incidence of EV-A71 infections was observed in children aged 5-6 months. Our findings support EV-A71 vaccination before 6 months for birth cohorts in southern China, potentially with a one-time catch-up vaccination for children 6 months-5 years old. More regionally representative longitudinal seroepidemiological studies are needed to further validate these findings. Nature Publishing Group UK 2022-11-26 /pmc/articles/PMC9701185/ /pubmed/36435844 http://dx.doi.org/10.1038/s41467-022-34992-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yang, Juan
Liao, Qiaohong
Luo, Kaiwei
Liu, Fengfeng
Zhou, Yonghong
Zou, Gang
Huang, Wei
Yu, Shuanbao
Wei, Xianglin
Zhou, Jiaxin
Dai, Bingbing
Qiu, Qi
Altmeyer, Ralf
Hu, Hongan
Paireau, Juliette
Luo, Li
Gao, Lidong
Nikolay, Birgit
Hu, Shixiong
Xing, Weijia
Wu, Peng
van Doorn, H. Rogier
Horby, Peter W.
Simmonds, Peter
Leung, Gabriel M.
Cowling, Benjamin J.
Cauchemez, Simon
Yu, Hongjie
Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018
title Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018
title_full Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018
title_fullStr Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018
title_full_unstemmed Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018
title_short Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018
title_sort seroepidemiology of enterovirus a71 infection in prospective cohort studies of children in southern china, 2013-2018
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701185/
https://www.ncbi.nlm.nih.gov/pubmed/36435844
http://dx.doi.org/10.1038/s41467-022-34992-1
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