Greater genetic diversity is needed in human pluripotent stem cell models

While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and studies. Here, we discuss the importance of incorporating diverse ancestries in these models to improve equity and accelerate biological discovery.

Detalles Bibliográficos
Autores principales: Ghosh, Sulagna, Nehme, Ralda, Barrett, Lindy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701202/
https://www.ncbi.nlm.nih.gov/pubmed/36435871
http://dx.doi.org/10.1038/s41467-022-34940-z
_version_ 1784839485811326976
author Ghosh, Sulagna
Nehme, Ralda
Barrett, Lindy E.
author_facet Ghosh, Sulagna
Nehme, Ralda
Barrett, Lindy E.
author_sort Ghosh, Sulagna
collection PubMed
description While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and studies. Here, we discuss the importance of incorporating diverse ancestries in these models to improve equity and accelerate biological discovery.
format Online
Article
Text
id pubmed-9701202
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-97012022022-11-28 Greater genetic diversity is needed in human pluripotent stem cell models Ghosh, Sulagna Nehme, Ralda Barrett, Lindy E. Nat Commun Comment While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and studies. Here, we discuss the importance of incorporating diverse ancestries in these models to improve equity and accelerate biological discovery. Nature Publishing Group UK 2022-11-26 /pmc/articles/PMC9701202/ /pubmed/36435871 http://dx.doi.org/10.1038/s41467-022-34940-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Ghosh, Sulagna
Nehme, Ralda
Barrett, Lindy E.
Greater genetic diversity is needed in human pluripotent stem cell models
title Greater genetic diversity is needed in human pluripotent stem cell models
title_full Greater genetic diversity is needed in human pluripotent stem cell models
title_fullStr Greater genetic diversity is needed in human pluripotent stem cell models
title_full_unstemmed Greater genetic diversity is needed in human pluripotent stem cell models
title_short Greater genetic diversity is needed in human pluripotent stem cell models
title_sort greater genetic diversity is needed in human pluripotent stem cell models
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701202/
https://www.ncbi.nlm.nih.gov/pubmed/36435871
http://dx.doi.org/10.1038/s41467-022-34940-z
work_keys_str_mv AT ghoshsulagna greatergeneticdiversityisneededinhumanpluripotentstemcellmodels
AT nehmeralda greatergeneticdiversityisneededinhumanpluripotentstemcellmodels
AT barrettlindye greatergeneticdiversityisneededinhumanpluripotentstemcellmodels

Ejemplares similares