Cargando…
Chiral nanocrystals grown from MoS(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs
The transfer of the concept of chirality from molecules to synthesized nanomaterials has attracted attention amongst multidisciplinary teams. Here we demonstrate heterogeneous nucleation and anisotropic accumulation of Au nanoparticles on multilayer MoS(2) planes to form chiroptically functional nan...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701227/ https://www.ncbi.nlm.nih.gov/pubmed/36435865 http://dx.doi.org/10.1038/s41467-022-35016-8 |
_version_ | 1784839493519409152 |
---|---|
author | Li, Bang Lin Luo, Jun Jiang Zou, Hao Lin Zhang, Qing-Meng Zhao, Liu-Bin Qian, Hang Luo, Hong Qun Leong, David Tai Li, Nian Bing |
author_facet | Li, Bang Lin Luo, Jun Jiang Zou, Hao Lin Zhang, Qing-Meng Zhao, Liu-Bin Qian, Hang Luo, Hong Qun Leong, David Tai Li, Nian Bing |
author_sort | Li, Bang Lin |
collection | PubMed |
description | The transfer of the concept of chirality from molecules to synthesized nanomaterials has attracted attention amongst multidisciplinary teams. Here we demonstrate heterogeneous nucleation and anisotropic accumulation of Au nanoparticles on multilayer MoS(2) planes to form chiroptically functional nanomaterials. Thiol amino acids with chiral conformations modulate asymmetric growth of gold nanoarchitectures on seeds of highly faceted Au/MoS(2) heterostructures. Consequently, dendritic plasmonic nanocrystals with partial chiral morphologies are synthesized. The chirality of dendritic nanocrystals inherited from cysteine molecules refers to the structural characteristics and includes specific recognition of enantiomeric molecules. With integration of the intrinsic photothermal properties and inherited enantioselective characteristics, dendritic Au/MoS(2) heterostructures exhibit chirality-dependent release of antimicrobial drugs from hydrogel substrates when activated by exogenous infrared irradiation. A three-in-one strategy involving synthesis of chiral dendritic heterostructures, enantioselective recognition, and controlled drug release system is presented, which improves nanomaterial synthetic technology and enhances our understanding of crucial chirality information. |
format | Online Article Text |
id | pubmed-9701227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97012272022-11-28 Chiral nanocrystals grown from MoS(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs Li, Bang Lin Luo, Jun Jiang Zou, Hao Lin Zhang, Qing-Meng Zhao, Liu-Bin Qian, Hang Luo, Hong Qun Leong, David Tai Li, Nian Bing Nat Commun Article The transfer of the concept of chirality from molecules to synthesized nanomaterials has attracted attention amongst multidisciplinary teams. Here we demonstrate heterogeneous nucleation and anisotropic accumulation of Au nanoparticles on multilayer MoS(2) planes to form chiroptically functional nanomaterials. Thiol amino acids with chiral conformations modulate asymmetric growth of gold nanoarchitectures on seeds of highly faceted Au/MoS(2) heterostructures. Consequently, dendritic plasmonic nanocrystals with partial chiral morphologies are synthesized. The chirality of dendritic nanocrystals inherited from cysteine molecules refers to the structural characteristics and includes specific recognition of enantiomeric molecules. With integration of the intrinsic photothermal properties and inherited enantioselective characteristics, dendritic Au/MoS(2) heterostructures exhibit chirality-dependent release of antimicrobial drugs from hydrogel substrates when activated by exogenous infrared irradiation. A three-in-one strategy involving synthesis of chiral dendritic heterostructures, enantioselective recognition, and controlled drug release system is presented, which improves nanomaterial synthetic technology and enhances our understanding of crucial chirality information. Nature Publishing Group UK 2022-11-26 /pmc/articles/PMC9701227/ /pubmed/36435865 http://dx.doi.org/10.1038/s41467-022-35016-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Bang Lin Luo, Jun Jiang Zou, Hao Lin Zhang, Qing-Meng Zhao, Liu-Bin Qian, Hang Luo, Hong Qun Leong, David Tai Li, Nian Bing Chiral nanocrystals grown from MoS(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs |
title | Chiral nanocrystals grown from MoS(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs |
title_full | Chiral nanocrystals grown from MoS(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs |
title_fullStr | Chiral nanocrystals grown from MoS(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs |
title_full_unstemmed | Chiral nanocrystals grown from MoS(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs |
title_short | Chiral nanocrystals grown from MoS(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs |
title_sort | chiral nanocrystals grown from mos(2) nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701227/ https://www.ncbi.nlm.nih.gov/pubmed/36435865 http://dx.doi.org/10.1038/s41467-022-35016-8 |
work_keys_str_mv | AT libanglin chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs AT luojunjiang chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs AT zouhaolin chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs AT zhangqingmeng chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs AT zhaoliubin chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs AT qianhang chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs AT luohongqun chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs AT leongdavidtai chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs AT linianbing chiralnanocrystalsgrownfrommos2nanosheetsenablephotothermallymodulatedenantioselectivereleaseofantimicrobialdrugs |