Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids

TGFβ1 plays a regulatory role in the determination of renal cell fate and the progression of renal fibrosis. Here we show an association between SMAD3 and the histone methyltransferase, EZH2, during cell differentiation; ChIP-seq revealed that SMAD3 and EZH2 co-occupy the genome in iPSCs and in iPSC...

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Detalles Bibliográficos
Autores principales: Davis, Jessica L., Kennedy, Ciaran, Clerkin, Shane, Treacy, Niall J., Dodd, Thomas, Moss, Catherine, Murphy, Alison, Brazil, Derek P., Cagney, Gerard, Brougham, Dermot F., Murad, Rabi, Finlay, Darren, Vuori, Kristiina, Crean, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701233/
https://www.ncbi.nlm.nih.gov/pubmed/36435939
http://dx.doi.org/10.1038/s42003-022-04264-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701233/
https://www.ncbi.nlm.nih.gov/pubmed/36435939
http://dx.doi.org/10.1038/s42003-022-04264-1

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