NPRL2 down‐regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression

Hepatocellular carcinoma (HCC) is a highly invasive malignancy. Recently, GATOR1 (Gap Activity TOward Rags 1) complexes have been shown to play an important role in regulating tumor growth. NPRL2 is a critical component of the GATOR1 complex. Therefore, this study used NPRL2 knockdown to investigate...

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Detalles Bibliográficos
Autores principales: Wang, Ya‐Chin, Tsai, Ming‐Chao, Chen, Yaw‐Sen, Hsieh, Pei‐Min, Hung, Chao‐Ming, Lin, Hung‐Yu, Hsu, Yao‐Chun, Yeh, Jen‐Hao, Hsiao, Pojen, Su, Yu‐Cheih, Ma, Ching‐Hou, Lee, Chih‐Yuan, Lin, Chih‐Che, Shu, Chih‐Wen, Li, Yu‐Chan, Tsai, Mei‐Hsing, Lin, James Yu, Peng, Wei‐Hao, Yu, Ming‐Lung, Lin, Chih‐Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701468/
https://www.ncbi.nlm.nih.gov/pubmed/36321403
http://dx.doi.org/10.1002/hep4.2019

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