Cargando…
CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease
BACKGROUND: Hyperphosphorylation of tau leads to conformational changes that destabilize microtubules and hinder axonal transport in Alzheimer’s disease (AD). However, it remains unknown whether white matter (WM) decline due to AD is associated with specific Tau phosphorylation site(s). METHODS: In...
Autores principales: | Strain, Jeremy F., Barthelemy, Nicolas, Horie, Kanta, Gordon, Brian A., Kilgore, Collin, Aschenbrenner, Andrew, Cruchaga, Carlos, Xiong, Chengjie, Joseph-Mathurin, Nelly, Hassenstab, Jason, Fagan, Anne M., Li, Yan, Karch, Celeste M., Perrin, Richard J., Berman, Sarah B., Chhatwal, Jasmeer P., Graff-Radford, Neill R., Mori, Hiroshi, Levin, Johannes, Noble, James M., Allegri, Ricardo, Schofield, Peter R., Marcus, Daniel S., Holtzman, David M., Morris, John C., Benzinger, Tammie L.S., McDade, Eric M., Bateman, Randall J., Ances, Beau M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701560/ https://www.ncbi.nlm.nih.gov/pubmed/35358703 http://dx.doi.org/10.1016/j.nbd.2022.105714 |
Ejemplares similares
-
Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease
por: Wang, Guoqiao, et al.
Publicado: (2018) -
Relationships between big‐five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease
por: Aschenbrenner, Andrew J., et al.
Publicado: (2020) -
Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease
por: Wang, Guoqiao, et al.
Publicado: (2019) -
Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease
por: Llibre-Guerra, Jorge J., et al.
Publicado: (2019) -
Discovery and validation of autosomal dominant Alzheimer’s disease mutations
por: Hsu, Simon, et al.
Publicado: (2018)