Brain stem encephalitis is a rare complication of COVID-19

Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate the SARS-CoV-2 antibody index as a tool to differentiate between a direct (viral) and indirect etiology. Out of >4000 hospitalized patients with COVID-19, we included 13 patients with neurological symptoms wit...

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Detalles Bibliográficos
Autores principales: Shamier, Marc C., Crijnen, Yvette S., Bogers, Susanne, IJpelaar, Jeroen W., de Vries, Juna M., van der Jagt, Mathieu, Spoor, Jochem K.H., von der Thüsen, Jan H., Schreurs, Marco W.J., GeurtsvanKessel, Corine H., Titulaer, Maarten J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701569/
https://www.ncbi.nlm.nih.gov/pubmed/36481703
http://dx.doi.org/10.1016/j.jneuroim.2022.578007
Descripción
Sumario:Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate the SARS-CoV-2 antibody index as a tool to differentiate between a direct (viral) and indirect etiology. Out of >4000 hospitalized patients with COVID-19, we included 13 patients with neurological symptoms with suspicion of neuroinflammation. On clinical grounds, eight were classified as having a possible/probable relationship between neurological symptoms and COVID-19. A clinically distinctive phenotype of brainstem and cerebellar symptoms was seen in 6/8 patients. As we found a positive SARS-CoV-2 antibody index in 3/5 patients, indicating specific intrathecal SARS-CoV-2 IgG production, a direct link with SARS-CoV-2 is likely.

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