Brain stem encephalitis is a rare complication of COVID-19

Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate the SARS-CoV-2 antibody index as a tool to differentiate between a direct (viral) and indirect etiology. Out of >4000 hospitalized patients with COVID-19, we included 13 patients with neurological symptoms wit...

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Autores principales: Shamier, Marc C., Crijnen, Yvette S., Bogers, Susanne, IJpelaar, Jeroen W., de Vries, Juna M., van der Jagt, Mathieu, Spoor, Jochem K.H., von der Thüsen, Jan H., Schreurs, Marco W.J., GeurtsvanKessel, Corine H., Titulaer, Maarten J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701569/
https://www.ncbi.nlm.nih.gov/pubmed/36481703
http://dx.doi.org/10.1016/j.jneuroim.2022.578007
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author Shamier, Marc C.
Crijnen, Yvette S.
Bogers, Susanne
IJpelaar, Jeroen W.
de Vries, Juna M.
van der Jagt, Mathieu
Spoor, Jochem K.H.
von der Thüsen, Jan H.
Schreurs, Marco W.J.
GeurtsvanKessel, Corine H.
Titulaer, Maarten J.
author_facet Shamier, Marc C.
Crijnen, Yvette S.
Bogers, Susanne
IJpelaar, Jeroen W.
de Vries, Juna M.
van der Jagt, Mathieu
Spoor, Jochem K.H.
von der Thüsen, Jan H.
Schreurs, Marco W.J.
GeurtsvanKessel, Corine H.
Titulaer, Maarten J.
author_sort Shamier, Marc C.
collection PubMed
description Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate the SARS-CoV-2 antibody index as a tool to differentiate between a direct (viral) and indirect etiology. Out of >4000 hospitalized patients with COVID-19, we included 13 patients with neurological symptoms with suspicion of neuroinflammation. On clinical grounds, eight were classified as having a possible/probable relationship between neurological symptoms and COVID-19. A clinically distinctive phenotype of brainstem and cerebellar symptoms was seen in 6/8 patients. As we found a positive SARS-CoV-2 antibody index in 3/5 patients, indicating specific intrathecal SARS-CoV-2 IgG production, a direct link with SARS-CoV-2 is likely.
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spelling pubmed-97015692022-11-28 Brain stem encephalitis is a rare complication of COVID-19 Shamier, Marc C. Crijnen, Yvette S. Bogers, Susanne IJpelaar, Jeroen W. de Vries, Juna M. van der Jagt, Mathieu Spoor, Jochem K.H. von der Thüsen, Jan H. Schreurs, Marco W.J. GeurtsvanKessel, Corine H. Titulaer, Maarten J. J Neuroimmunol Short Communication Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate the SARS-CoV-2 antibody index as a tool to differentiate between a direct (viral) and indirect etiology. Out of >4000 hospitalized patients with COVID-19, we included 13 patients with neurological symptoms with suspicion of neuroinflammation. On clinical grounds, eight were classified as having a possible/probable relationship between neurological symptoms and COVID-19. A clinically distinctive phenotype of brainstem and cerebellar symptoms was seen in 6/8 patients. As we found a positive SARS-CoV-2 antibody index in 3/5 patients, indicating specific intrathecal SARS-CoV-2 IgG production, a direct link with SARS-CoV-2 is likely. The Authors. Published by Elsevier B.V. 2023-01-15 2022-11-28 /pmc/articles/PMC9701569/ /pubmed/36481703 http://dx.doi.org/10.1016/j.jneuroim.2022.578007 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Shamier, Marc C.
Crijnen, Yvette S.
Bogers, Susanne
IJpelaar, Jeroen W.
de Vries, Juna M.
van der Jagt, Mathieu
Spoor, Jochem K.H.
von der Thüsen, Jan H.
Schreurs, Marco W.J.
GeurtsvanKessel, Corine H.
Titulaer, Maarten J.
Brain stem encephalitis is a rare complication of COVID-19
title Brain stem encephalitis is a rare complication of COVID-19
title_full Brain stem encephalitis is a rare complication of COVID-19
title_fullStr Brain stem encephalitis is a rare complication of COVID-19
title_full_unstemmed Brain stem encephalitis is a rare complication of COVID-19
title_short Brain stem encephalitis is a rare complication of COVID-19
title_sort brain stem encephalitis is a rare complication of covid-19
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701569/
https://www.ncbi.nlm.nih.gov/pubmed/36481703
http://dx.doi.org/10.1016/j.jneuroim.2022.578007
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