Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier

Effective delivery of therapeutics to the brain is challenging. Molecular shuttles use receptors expressed on brain endothelial cells to deliver therapeutics. Antibodies targeting transferrin receptor (TfR) have been widely developed as molecular shuttles. However, the TfR-based approach raises conc...

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Detalles Bibliográficos
Autores principales: Shin, Jung-Won, An, Sungwon, Kim, Dongin, Kim, Hyunjoo, Ahn, Jinhyung, Eom, Jaehyun, You, Weon-Kyoo, Yun, Hyesu, Lee, Bora, Sung, Byungje, Jung, Jinwon, Kim, Sehyun, Son, Yonggyu, Sung, Eunsil, Lee, Hanbyul, Lee, Suyeon, Song, Daehae, Pak, Youngdon, Sandhu, Jagdeep K., Haqqani, Arsalan S., Stanimirovic, Danica B., Yoo, Jiseon, Kim, Donghwan, Maeng, Sungho, Lee, Jeonghun, Lee, Sang Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701613/
https://www.ncbi.nlm.nih.gov/pubmed/36452865
http://dx.doi.org/10.1016/j.crmeth.2022.100338

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