Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML

NPM1 is the most frequently mutated gene in adults with acute myeloid leukemia (AML). The interaction between mutant NPM1 (NPM1c) and exportin-1 (XPO1) causes aberrant cytoplasmic dislocation of NPM1c and promotes the high expression of homeobox (HOX) genes, which is critical for maintaining the leu...

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Detalles Bibliográficos
Autores principales: Pianigiani, Giulia, Gagliardi, Andrea, Mezzasoma, Federica, Rocchio, Francesca, Tini, Valentina, Bigerna, Barbara, Sportoletti, Paolo, Caruso, Simona, Marra, Andrea, Peruzzi, Sara, Petito, Eleonora, Spinozzi, Giulio, Shacham, Sharon, Landesman, Yosef, Quintarelli, Concetta, Gresele, Paolo, Locatelli, Franco, Martelli, Maria Paola, Falini, Brunangelo, Brunetti, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701620/
https://www.ncbi.nlm.nih.gov/pubmed/36037515
http://dx.doi.org/10.1182/bloodadvances.2022007563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701620/
https://www.ncbi.nlm.nih.gov/pubmed/36037515
http://dx.doi.org/10.1182/bloodadvances.2022007563

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