Seven classes of antiviral agents

The viral epidemics and pandemics have stimulated the development of known and the discovery of novel antiviral agents. About a hundred mono- and combination antiviral drugs have been already approved, whereas thousands are in development. Here, we briefly reviewed 7 classes of antiviral agents: neu...

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Autores principales: Ianevski, Aleksandr, Ahmad, Shahzaib, Anunnitipat, Kraipit, Oksenych, Valentyn, Zusinaite, Eva, Tenson, Tanel, Bjørås, Magnar, Kainov, Denis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701656/
https://www.ncbi.nlm.nih.gov/pubmed/36436108
http://dx.doi.org/10.1007/s00018-022-04635-1
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author Ianevski, Aleksandr
Ahmad, Shahzaib
Anunnitipat, Kraipit
Oksenych, Valentyn
Zusinaite, Eva
Tenson, Tanel
Bjørås, Magnar
Kainov, Denis E.
author_facet Ianevski, Aleksandr
Ahmad, Shahzaib
Anunnitipat, Kraipit
Oksenych, Valentyn
Zusinaite, Eva
Tenson, Tanel
Bjørås, Magnar
Kainov, Denis E.
author_sort Ianevski, Aleksandr
collection PubMed
description The viral epidemics and pandemics have stimulated the development of known and the discovery of novel antiviral agents. About a hundred mono- and combination antiviral drugs have been already approved, whereas thousands are in development. Here, we briefly reviewed 7 classes of antiviral agents: neutralizing antibodies, neutralizing recombinant soluble human receptors, antiviral CRISPR/Cas systems, interferons, antiviral peptides, antiviral nucleic acid polymers, and antiviral small molecules. Interferons and some small molecules alone or in combinations possess broad-spectrum antiviral activity, which could be beneficial for treatment of emerging and re-emerging viral infections. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00018-022-04635-1.
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spelling pubmed-97016562022-11-28 Seven classes of antiviral agents Ianevski, Aleksandr Ahmad, Shahzaib Anunnitipat, Kraipit Oksenych, Valentyn Zusinaite, Eva Tenson, Tanel Bjørås, Magnar Kainov, Denis E. Cell Mol Life Sci Review The viral epidemics and pandemics have stimulated the development of known and the discovery of novel antiviral agents. About a hundred mono- and combination antiviral drugs have been already approved, whereas thousands are in development. Here, we briefly reviewed 7 classes of antiviral agents: neutralizing antibodies, neutralizing recombinant soluble human receptors, antiviral CRISPR/Cas systems, interferons, antiviral peptides, antiviral nucleic acid polymers, and antiviral small molecules. Interferons and some small molecules alone or in combinations possess broad-spectrum antiviral activity, which could be beneficial for treatment of emerging and re-emerging viral infections. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00018-022-04635-1. Springer International Publishing 2022-11-27 2022 /pmc/articles/PMC9701656/ /pubmed/36436108 http://dx.doi.org/10.1007/s00018-022-04635-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ianevski, Aleksandr
Ahmad, Shahzaib
Anunnitipat, Kraipit
Oksenych, Valentyn
Zusinaite, Eva
Tenson, Tanel
Bjørås, Magnar
Kainov, Denis E.
Seven classes of antiviral agents
title Seven classes of antiviral agents
title_full Seven classes of antiviral agents
title_fullStr Seven classes of antiviral agents
title_full_unstemmed Seven classes of antiviral agents
title_short Seven classes of antiviral agents
title_sort seven classes of antiviral agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701656/
https://www.ncbi.nlm.nih.gov/pubmed/36436108
http://dx.doi.org/10.1007/s00018-022-04635-1
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