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Understanding the dynamics of fluid–structure interaction with an Air Deflected Microfluidic Chip (ADMC)
A deformable microfluidic system and a fluidic dynamic model have been successfully coupled to understand the dynamic fluid–structure interaction in transient flow, designed to understand the dentine hypersensitivity caused by hydrodynamic theory. The Polydimethylsiloxane thin sidewalls of the micro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701768/ https://www.ncbi.nlm.nih.gov/pubmed/36437301 http://dx.doi.org/10.1038/s41598-022-24112-w |
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author | Pas, Chad ten Du, Ke Pan, Long Wang, Ruo-Qian Xu, Shiyou |
author_facet | Pas, Chad ten Du, Ke Pan, Long Wang, Ruo-Qian Xu, Shiyou |
author_sort | Pas, Chad ten |
collection | PubMed |
description | A deformable microfluidic system and a fluidic dynamic model have been successfully coupled to understand the dynamic fluid–structure interaction in transient flow, designed to understand the dentine hypersensitivity caused by hydrodynamic theory. The Polydimethylsiloxane thin sidewalls of the microfluidic chip are deformed with air pressure ranging from 50 to 500 mbar to move the liquid meniscus in the central liquid channel. The experiments show that the meniscus sharply increased in the first 10th of second and the increase is nonlinearly proportional to the applied pressure. A theoretical model is developed based on the unsteady Bernoulli equation and can well predict the ending point of the liquid displacement as well as the dynamics process, regardless of the wall thickness. Moreover, an overshooting and oscillation phenomenon is observed by reducing the head loss coefficient by a few orders which could be the key to explain the dentine hypersensitivity caused by the liquid movement in the dentine tubules. |
format | Online Article Text |
id | pubmed-9701768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97017682022-11-29 Understanding the dynamics of fluid–structure interaction with an Air Deflected Microfluidic Chip (ADMC) Pas, Chad ten Du, Ke Pan, Long Wang, Ruo-Qian Xu, Shiyou Sci Rep Article A deformable microfluidic system and a fluidic dynamic model have been successfully coupled to understand the dynamic fluid–structure interaction in transient flow, designed to understand the dentine hypersensitivity caused by hydrodynamic theory. The Polydimethylsiloxane thin sidewalls of the microfluidic chip are deformed with air pressure ranging from 50 to 500 mbar to move the liquid meniscus in the central liquid channel. The experiments show that the meniscus sharply increased in the first 10th of second and the increase is nonlinearly proportional to the applied pressure. A theoretical model is developed based on the unsteady Bernoulli equation and can well predict the ending point of the liquid displacement as well as the dynamics process, regardless of the wall thickness. Moreover, an overshooting and oscillation phenomenon is observed by reducing the head loss coefficient by a few orders which could be the key to explain the dentine hypersensitivity caused by the liquid movement in the dentine tubules. Nature Publishing Group UK 2022-11-27 /pmc/articles/PMC9701768/ /pubmed/36437301 http://dx.doi.org/10.1038/s41598-022-24112-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Pas, Chad ten Du, Ke Pan, Long Wang, Ruo-Qian Xu, Shiyou Understanding the dynamics of fluid–structure interaction with an Air Deflected Microfluidic Chip (ADMC) |
title | Understanding the dynamics of fluid–structure interaction with an Air Deflected Microfluidic Chip (ADMC) |
title_full | Understanding the dynamics of fluid–structure interaction with an Air Deflected Microfluidic Chip (ADMC) |
title_fullStr | Understanding the dynamics of fluid–structure interaction with an Air Deflected Microfluidic Chip (ADMC) |
title_full_unstemmed | Understanding the dynamics of fluid–structure interaction with an Air Deflected Microfluidic Chip (ADMC) |
title_short | Understanding the dynamics of fluid–structure interaction with an Air Deflected Microfluidic Chip (ADMC) |
title_sort | understanding the dynamics of fluid–structure interaction with an air deflected microfluidic chip (admc) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701768/ https://www.ncbi.nlm.nih.gov/pubmed/36437301 http://dx.doi.org/10.1038/s41598-022-24112-w |
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