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Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia

Blocked cellular differentiation is a critical pathologic hallmark of acute myeloid leukemia (AML). Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation of AML both in vitro and in vivo, indicating that GPR132 is a potential trigger of myeloid...

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Detalles Bibliográficos
Autores principales:	Yi, Chunyang, He, Jiacheng, Huang, Dan, Zhao, Yumiao, Zhang, Chan, Ye, Xiyun, Huang, Ying, Nussinov, Ruth, Zheng, Junke, Liu, Mingyao, Lu, Weiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701798/ https://www.ncbi.nlm.nih.gov/pubmed/36437247 http://dx.doi.org/10.1038/s41419-022-05434-z

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