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Case report: Disseminated histoplasmosis in a renal transplant recipient from a non-endemic region
Histoplasmosis is the most common endemic fungal infection in the USA. The majority of cases are asymptomatic and have clear exposure to endemic regions. In contrast, we present an adolescent immunocompromised patient with systemic and relatively non-specific symptoms including abdominal pain, weigh...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701819/ https://www.ncbi.nlm.nih.gov/pubmed/36452357 http://dx.doi.org/10.3389/fped.2022.985475 |
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author | Chang, Brian Saleh, Tawny Wales, Cameron Kuklinski, Lawrence Malla, Prerana Yang, Shangxin Fuller, David Nielsen-Saines, Karin |
author_facet | Chang, Brian Saleh, Tawny Wales, Cameron Kuklinski, Lawrence Malla, Prerana Yang, Shangxin Fuller, David Nielsen-Saines, Karin |
author_sort | Chang, Brian |
collection | PubMed |
description | Histoplasmosis is the most common endemic fungal infection in the USA. The majority of cases are asymptomatic and have clear exposure to endemic regions. In contrast, we present an adolescent immunocompromised patient with systemic and relatively non-specific symptoms including abdominal pain, weight loss, lower extremity edema, and scabbing skin lesions, without known exposure to endemic areas for histoplasmosis. Histologic analysis of gastrointestinal and skin biopsies eventually revealed a diagnosis of disseminated histoplasmosis; the patient was successfully treated with amphotericin B followed by itraconazole maintenance therapy. Ultimately, a high bar of suspicion for fungal disease must be maintained in immunosuppressed individuals even without apparent exposure history to endemic areas. This case report serves as a valuable reference for practitioners evaluating differential diagnosis of infections in immunocompromised patients. |
format | Online Article Text |
id | pubmed-9701819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97018192022-11-29 Case report: Disseminated histoplasmosis in a renal transplant recipient from a non-endemic region Chang, Brian Saleh, Tawny Wales, Cameron Kuklinski, Lawrence Malla, Prerana Yang, Shangxin Fuller, David Nielsen-Saines, Karin Front Pediatr Pediatrics Histoplasmosis is the most common endemic fungal infection in the USA. The majority of cases are asymptomatic and have clear exposure to endemic regions. In contrast, we present an adolescent immunocompromised patient with systemic and relatively non-specific symptoms including abdominal pain, weight loss, lower extremity edema, and scabbing skin lesions, without known exposure to endemic areas for histoplasmosis. Histologic analysis of gastrointestinal and skin biopsies eventually revealed a diagnosis of disseminated histoplasmosis; the patient was successfully treated with amphotericin B followed by itraconazole maintenance therapy. Ultimately, a high bar of suspicion for fungal disease must be maintained in immunosuppressed individuals even without apparent exposure history to endemic areas. This case report serves as a valuable reference for practitioners evaluating differential diagnosis of infections in immunocompromised patients. Frontiers Media S.A. 2022-11-14 /pmc/articles/PMC9701819/ /pubmed/36452357 http://dx.doi.org/10.3389/fped.2022.985475 Text en © 2022 Chang, Saleh, Wales, Kuklinski, Malla, Yang, Fuller and Nielsen-Saines. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Chang, Brian Saleh, Tawny Wales, Cameron Kuklinski, Lawrence Malla, Prerana Yang, Shangxin Fuller, David Nielsen-Saines, Karin Case report: Disseminated histoplasmosis in a renal transplant recipient from a non-endemic region |
title | Case report: Disseminated histoplasmosis in a renal transplant recipient from a non-endemic region |
title_full | Case report: Disseminated histoplasmosis in a renal transplant recipient from a non-endemic region |
title_fullStr | Case report: Disseminated histoplasmosis in a renal transplant recipient from a non-endemic region |
title_full_unstemmed | Case report: Disseminated histoplasmosis in a renal transplant recipient from a non-endemic region |
title_short | Case report: Disseminated histoplasmosis in a renal transplant recipient from a non-endemic region |
title_sort | case report: disseminated histoplasmosis in a renal transplant recipient from a non-endemic region |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701819/ https://www.ncbi.nlm.nih.gov/pubmed/36452357 http://dx.doi.org/10.3389/fped.2022.985475 |
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