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Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a typical immune-mediated chronic inflammatory disorder. Following the industrialization and changes in lifestyle, the incidence of IBD in the world is rising, which makes health concerns and heavy burdens all over the world. However, the pathogenesis of IBD remai...

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Autores principales: Li, Yue, Law, Helen Ka Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702352/
https://www.ncbi.nlm.nih.gov/pubmed/36452236
http://dx.doi.org/10.3389/fphar.2022.1070184
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author Li, Yue
Law, Helen Ka Wai
author_facet Li, Yue
Law, Helen Ka Wai
author_sort Li, Yue
collection PubMed
description Inflammatory bowel disease (IBD) is a typical immune-mediated chronic inflammatory disorder. Following the industrialization and changes in lifestyle, the incidence of IBD in the world is rising, which makes health concerns and heavy burdens all over the world. However, the pathogenesis of IBD remains unclear, and the current understanding of the pathogenesis involves dysregulation of mucosal immunity, gut microbiome dysbiosis, and gut barrier defect based on genetic susceptibility and environmental triggers. In recent years, autophagy has emerged as a key mechanism in IBD development and progression because Genome-Wide Association Study revealed the complex interactions of autophagy in IBD, especially immunopathogenesis. Besides, autophagy markers are also suggested to be potential biomarkers and target treatment in IBD. This review summarizes the autophagy-related genes regulating immune response in IBD. Furthermore, we explore the evolving evidence that autophagy interacts with intestinal epithelial and immune cells to contribute to the inflammatory changes in IBD. Finally, we discuss how novel discovery could further advance our understanding of the role of autophagy and inform novel therapeutic strategies in IBD.
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spelling pubmed-97023522022-11-29 Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease Li, Yue Law, Helen Ka Wai Front Pharmacol Pharmacology Inflammatory bowel disease (IBD) is a typical immune-mediated chronic inflammatory disorder. Following the industrialization and changes in lifestyle, the incidence of IBD in the world is rising, which makes health concerns and heavy burdens all over the world. However, the pathogenesis of IBD remains unclear, and the current understanding of the pathogenesis involves dysregulation of mucosal immunity, gut microbiome dysbiosis, and gut barrier defect based on genetic susceptibility and environmental triggers. In recent years, autophagy has emerged as a key mechanism in IBD development and progression because Genome-Wide Association Study revealed the complex interactions of autophagy in IBD, especially immunopathogenesis. Besides, autophagy markers are also suggested to be potential biomarkers and target treatment in IBD. This review summarizes the autophagy-related genes regulating immune response in IBD. Furthermore, we explore the evolving evidence that autophagy interacts with intestinal epithelial and immune cells to contribute to the inflammatory changes in IBD. Finally, we discuss how novel discovery could further advance our understanding of the role of autophagy and inform novel therapeutic strategies in IBD. Frontiers Media S.A. 2022-11-14 /pmc/articles/PMC9702352/ /pubmed/36452236 http://dx.doi.org/10.3389/fphar.2022.1070184 Text en Copyright © 2022 Li and Law. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Yue
Law, Helen Ka Wai
Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease
title Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease
title_full Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease
title_fullStr Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease
title_full_unstemmed Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease
title_short Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease
title_sort deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702352/
https://www.ncbi.nlm.nih.gov/pubmed/36452236
http://dx.doi.org/10.3389/fphar.2022.1070184
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