Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection

Avian leukemia virus subgroup A (ALV-A) infection slows chicken growth, immunosuppression, and tumor occurrence, causing economic loss to the poultry industry. According to previous findings, A20 has a dual role in promoting and inhibiting tumor formation but has rarely been studied in avians. In th...

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Autores principales: Chen, Xueyang, Wang, Xingming, Yang, Yuxin, Fang, Chun, Liu, Jing, Liang, Xiongyan, Yang, Yuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702354/
https://www.ncbi.nlm.nih.gov/pubmed/36452148
http://dx.doi.org/10.3389/fvets.2022.1031480
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author Chen, Xueyang
Wang, Xingming
Yang, Yuxin
Fang, Chun
Liu, Jing
Liang, Xiongyan
Yang, Yuying
author_facet Chen, Xueyang
Wang, Xingming
Yang, Yuxin
Fang, Chun
Liu, Jing
Liang, Xiongyan
Yang, Yuying
author_sort Chen, Xueyang
collection PubMed
description Avian leukemia virus subgroup A (ALV-A) infection slows chicken growth, immunosuppression, and tumor occurrence, causing economic loss to the poultry industry. According to previous findings, A20 has a dual role in promoting and inhibiting tumor formation but has rarely been studied in avians. In this study, A20 overexpression and shRNA interference recombinant adenoviruses were constructed and inoculated into chicken embryos, and ALV-A (rHB2015012) was inoculated into 1-day-old chicks. Analysis of body weight, organ index, detoxification, antibody production, organ toxin load, and Pathological observation revealed that A20 overexpression could enhance ALV-A pathogenicity. This study lays the foundation for subsequent exploration of the A20-mediated tumorigenic mechanism of ALV-A.
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spelling pubmed-97023542022-11-29 Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection Chen, Xueyang Wang, Xingming Yang, Yuxin Fang, Chun Liu, Jing Liang, Xiongyan Yang, Yuying Front Vet Sci Veterinary Science Avian leukemia virus subgroup A (ALV-A) infection slows chicken growth, immunosuppression, and tumor occurrence, causing economic loss to the poultry industry. According to previous findings, A20 has a dual role in promoting and inhibiting tumor formation but has rarely been studied in avians. In this study, A20 overexpression and shRNA interference recombinant adenoviruses were constructed and inoculated into chicken embryos, and ALV-A (rHB2015012) was inoculated into 1-day-old chicks. Analysis of body weight, organ index, detoxification, antibody production, organ toxin load, and Pathological observation revealed that A20 overexpression could enhance ALV-A pathogenicity. This study lays the foundation for subsequent exploration of the A20-mediated tumorigenic mechanism of ALV-A. Frontiers Media S.A. 2022-11-14 /pmc/articles/PMC9702354/ /pubmed/36452148 http://dx.doi.org/10.3389/fvets.2022.1031480 Text en Copyright © 2022 Chen, Wang, Yang, Fang, Liu, Liang and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Chen, Xueyang
Wang, Xingming
Yang, Yuxin
Fang, Chun
Liu, Jing
Liang, Xiongyan
Yang, Yuying
Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection
title Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection
title_full Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection
title_fullStr Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection
title_full_unstemmed Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection
title_short Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection
title_sort enhanced pathogenicity by up-regulation of a20 after avian leukemia subgroup a virus infection
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702354/
https://www.ncbi.nlm.nih.gov/pubmed/36452148
http://dx.doi.org/10.3389/fvets.2022.1031480
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