Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy

Tumor-specific T cells (TSTs) are essential components for the success of personalized tumor-infiltrating lymphocyte (TIL)-based adoptive cellular therapy (ACT). Therefore, the selection of a common biomarker for screening TSTs in different tumor types, followed by ex vivo expansion to clinical numb...

Descripción completa

Detalles Bibliográficos
Autores principales: Ge, Wu, Dong, Yuqian, Deng, Yao, Chen, Lujuan, Chen, Juan, Liu, Muqi, Wu, Jianmin, Wang, Wei, Ma, Xiaoqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702804/
https://www.ncbi.nlm.nih.gov/pubmed/36451828
http://dx.doi.org/10.3389/fimmu.2022.1003626
_version_ 1784839729484660736
author Ge, Wu
Dong, Yuqian
Deng, Yao
Chen, Lujuan
Chen, Juan
Liu, Muqi
Wu, Jianmin
Wang, Wei
Ma, Xiaoqian
author_facet Ge, Wu
Dong, Yuqian
Deng, Yao
Chen, Lujuan
Chen, Juan
Liu, Muqi
Wu, Jianmin
Wang, Wei
Ma, Xiaoqian
author_sort Ge, Wu
collection PubMed
description Tumor-specific T cells (TSTs) are essential components for the success of personalized tumor-infiltrating lymphocyte (TIL)-based adoptive cellular therapy (ACT). Therefore, the selection of a common biomarker for screening TSTs in different tumor types, followed by ex vivo expansion to clinical number levels can generate the greatest therapeutic effect. However, studies on shared biomarkers for TSTs have not been realized yet. The present review summarizes the similarities and differences of a number of biomarkers for TSTs in several tumor types studied in the last 5 years, and the advantages of combining biomarkers. In addition, the review discusses the possible shortcomings of current biomarkers and highlights strategies to identify TSTs accurately using intercellular interactions. Finally, the development of TSTs in personalized TIL-based ACT for broader clinical applications is explored.
format Online
Article
Text
id pubmed-9702804
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97028042022-11-29 Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy Ge, Wu Dong, Yuqian Deng, Yao Chen, Lujuan Chen, Juan Liu, Muqi Wu, Jianmin Wang, Wei Ma, Xiaoqian Front Immunol Immunology Tumor-specific T cells (TSTs) are essential components for the success of personalized tumor-infiltrating lymphocyte (TIL)-based adoptive cellular therapy (ACT). Therefore, the selection of a common biomarker for screening TSTs in different tumor types, followed by ex vivo expansion to clinical number levels can generate the greatest therapeutic effect. However, studies on shared biomarkers for TSTs have not been realized yet. The present review summarizes the similarities and differences of a number of biomarkers for TSTs in several tumor types studied in the last 5 years, and the advantages of combining biomarkers. In addition, the review discusses the possible shortcomings of current biomarkers and highlights strategies to identify TSTs accurately using intercellular interactions. Finally, the development of TSTs in personalized TIL-based ACT for broader clinical applications is explored. Frontiers Media S.A. 2022-11-14 /pmc/articles/PMC9702804/ /pubmed/36451828 http://dx.doi.org/10.3389/fimmu.2022.1003626 Text en Copyright © 2022 Ge, Dong, Deng, Chen, Chen, Liu, Wu, Wang and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ge, Wu
Dong, Yuqian
Deng, Yao
Chen, Lujuan
Chen, Juan
Liu, Muqi
Wu, Jianmin
Wang, Wei
Ma, Xiaoqian
Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy
title Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy
title_full Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy
title_fullStr Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy
title_full_unstemmed Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy
title_short Potential biomarkers: Identifying powerful tumor specific T cells in adoptive cellular therapy
title_sort potential biomarkers: identifying powerful tumor specific t cells in adoptive cellular therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702804/
https://www.ncbi.nlm.nih.gov/pubmed/36451828
http://dx.doi.org/10.3389/fimmu.2022.1003626
work_keys_str_mv AT gewu potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy
AT dongyuqian potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy
AT dengyao potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy
AT chenlujuan potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy
AT chenjuan potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy
AT liumuqi potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy
AT wujianmin potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy
AT wangwei potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy
AT maxiaoqian potentialbiomarkersidentifyingpowerfultumorspecifictcellsinadoptivecellulartherapy

Ejemplares similares