New Biomarkers in Anaphylaxis (Beyond Tryptase)

PURPOSE OF REVIEW: The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying mechanisms, effector cells, and the potential biomarkers involved depending on the anaphylaxis endotypes. RECENT FINDINGS: New insight into the potential rele...

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Detalles Bibliográficos
Autores principales: Galvan-Blasco, P., Gil-Serrano, J., Sala-Cunill, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Anaphylaxis (R Muñoz Cano, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702867/
https://www.ncbi.nlm.nih.gov/pubmed/36467524
http://dx.doi.org/10.1007/s40521-022-00326-1
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author Galvan-Blasco, P.
Gil-Serrano, J.
Sala-Cunill, A.
author_facet Galvan-Blasco, P.
Gil-Serrano, J.
Sala-Cunill, A.
author_sort Galvan-Blasco, P.
collection PubMed
description PURPOSE OF REVIEW: The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying mechanisms, effector cells, and the potential biomarkers involved depending on the anaphylaxis endotypes. RECENT FINDINGS: New insight into the potential relevance of pathways others than IgE-dependent anaphylaxis has been unraveled, as well as other biomarkers than tryptase, such as the role of platelet activation factor, basogranulin, dipeptidyl peptidase I, CCL-2, and other cytokines. SUMMARY: Gaining knowledge of all the mediators and cellular activation/communication pathways involved in each endotype of anaphylaxis will allow the application of precision medicine in patients with anaphylactic reactions, providing insights to the most appropriate approach in each case and helping to stratify severity and risk prediction.
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spelling pubmed-97028672022-11-28 New Biomarkers in Anaphylaxis (Beyond Tryptase) Galvan-Blasco, P. Gil-Serrano, J. Sala-Cunill, A. Curr Treat Options Allergy Anaphylaxis (R Muñoz Cano, Section Editor) PURPOSE OF REVIEW: The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying mechanisms, effector cells, and the potential biomarkers involved depending on the anaphylaxis endotypes. RECENT FINDINGS: New insight into the potential relevance of pathways others than IgE-dependent anaphylaxis has been unraveled, as well as other biomarkers than tryptase, such as the role of platelet activation factor, basogranulin, dipeptidyl peptidase I, CCL-2, and other cytokines. SUMMARY: Gaining knowledge of all the mediators and cellular activation/communication pathways involved in each endotype of anaphylaxis will allow the application of precision medicine in patients with anaphylactic reactions, providing insights to the most appropriate approach in each case and helping to stratify severity and risk prediction. Springer International Publishing 2022-11-28 2022 /pmc/articles/PMC9702867/ /pubmed/36467524 http://dx.doi.org/10.1007/s40521-022-00326-1 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Anaphylaxis (R Muñoz Cano, Section Editor)
Galvan-Blasco, P.
Gil-Serrano, J.
Sala-Cunill, A.
New Biomarkers in Anaphylaxis (Beyond Tryptase)
title New Biomarkers in Anaphylaxis (Beyond Tryptase)
title_full New Biomarkers in Anaphylaxis (Beyond Tryptase)
title_fullStr New Biomarkers in Anaphylaxis (Beyond Tryptase)
title_full_unstemmed New Biomarkers in Anaphylaxis (Beyond Tryptase)
title_short New Biomarkers in Anaphylaxis (Beyond Tryptase)
title_sort new biomarkers in anaphylaxis (beyond tryptase)
topic Anaphylaxis (R Muñoz Cano, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702867/
https://www.ncbi.nlm.nih.gov/pubmed/36467524
http://dx.doi.org/10.1007/s40521-022-00326-1
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