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Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination
Cases of myocarditis, diagnosed clinically by laboratory tests and imaging have been described in the context of mRNA-based anti-SARS-CoV-2 vaccination. Autopsy-based description of detailed histological features of vaccine-induced myocarditis is lacking. We describe the autopsy findings and common...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702955/ https://www.ncbi.nlm.nih.gov/pubmed/36436002 http://dx.doi.org/10.1007/s00392-022-02129-5 |
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author | Schwab, Constantin Domke, Lisa Maria Hartmann, Laura Stenzinger, Albrecht Longerich, Thomas Schirmacher, Peter |
author_facet | Schwab, Constantin Domke, Lisa Maria Hartmann, Laura Stenzinger, Albrecht Longerich, Thomas Schirmacher, Peter |
author_sort | Schwab, Constantin |
collection | PubMed |
description | Cases of myocarditis, diagnosed clinically by laboratory tests and imaging have been described in the context of mRNA-based anti-SARS-CoV-2 vaccination. Autopsy-based description of detailed histological features of vaccine-induced myocarditis is lacking. We describe the autopsy findings and common characteristics of myocarditis in untreated persons who received anti-SARS-CoV-2 vaccination. Standardized autopsies were performed on 25 persons who had died unexpectedly and within 20 days after anti-SARS-CoV-2 vaccination. In four patients who received a mRNA vaccination, we identified acute (epi-)myocarditis without detection of another significant disease or health constellation that may have caused an unexpected death. Histology showed patchy interstitial myocardial T-lymphocytic infiltration, predominantly of the CD4 positive subset, associated with mild myocyte damage. Overall, autopsy findings indicated death due to acute arrhythmogenic cardiac failure. Thus, myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination. Our findings may aid in adequately diagnosing unclear cases after vaccination and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00392-022-02129-5. |
format | Online Article Text |
id | pubmed-9702955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-97029552022-11-28 Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination Schwab, Constantin Domke, Lisa Maria Hartmann, Laura Stenzinger, Albrecht Longerich, Thomas Schirmacher, Peter Clin Res Cardiol Original Paper Cases of myocarditis, diagnosed clinically by laboratory tests and imaging have been described in the context of mRNA-based anti-SARS-CoV-2 vaccination. Autopsy-based description of detailed histological features of vaccine-induced myocarditis is lacking. We describe the autopsy findings and common characteristics of myocarditis in untreated persons who received anti-SARS-CoV-2 vaccination. Standardized autopsies were performed on 25 persons who had died unexpectedly and within 20 days after anti-SARS-CoV-2 vaccination. In four patients who received a mRNA vaccination, we identified acute (epi-)myocarditis without detection of another significant disease or health constellation that may have caused an unexpected death. Histology showed patchy interstitial myocardial T-lymphocytic infiltration, predominantly of the CD4 positive subset, associated with mild myocyte damage. Overall, autopsy findings indicated death due to acute arrhythmogenic cardiac failure. Thus, myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination. Our findings may aid in adequately diagnosing unclear cases after vaccination and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00392-022-02129-5. Springer Berlin Heidelberg 2022-11-27 2023 /pmc/articles/PMC9702955/ /pubmed/36436002 http://dx.doi.org/10.1007/s00392-022-02129-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Schwab, Constantin Domke, Lisa Maria Hartmann, Laura Stenzinger, Albrecht Longerich, Thomas Schirmacher, Peter Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination |
title | Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination |
title_full | Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination |
title_fullStr | Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination |
title_full_unstemmed | Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination |
title_short | Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination |
title_sort | autopsy-based histopathological characterization of myocarditis after anti-sars-cov-2-vaccination |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702955/ https://www.ncbi.nlm.nih.gov/pubmed/36436002 http://dx.doi.org/10.1007/s00392-022-02129-5 |
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