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TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer
• There is a lack of prospective level I evidence for the use of PBT for most adult cancers including oropharyngeal squamous cell carcinoma (OPSCC). • TORPEdO is the UK’s first PBT clinical trial and aims to determine the benefits of PBT for OPSCC. • Training and support has been provided before and...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702982/ https://www.ncbi.nlm.nih.gov/pubmed/36452431 http://dx.doi.org/10.1016/j.ctro.2022.11.010 |
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| author | Thomson, David J. Cruickshank, Clare Baines, Helen Banner, Russell Beasley, Matthew Betts, Guy Bulbeck, Helen Charlwood, Frances Christian, Judith Clarke, Matthew Donnelly, Olly Foran, Bernadette Gillies, Callum Griffin, Clare Homer, Jarrod J. Langendijk, Johannes A. Lee, Lip Wai Lester, James Lowe, Matthew McPartlin, Andrew Miles, Elizabeth Nutting, Christopher Palaniappan, Nachi Prestwich, Robin Price, James M. Roberts, Clare Roe, Justin Shanmugasundaram, Ramkumar Simões, Rita Thompson, Anna West, Catharine Wilson, Lorna Wolstenholme, Jane Hall, Emma |
| author_facet | Thomson, David J. Cruickshank, Clare Baines, Helen Banner, Russell Beasley, Matthew Betts, Guy Bulbeck, Helen Charlwood, Frances Christian, Judith Clarke, Matthew Donnelly, Olly Foran, Bernadette Gillies, Callum Griffin, Clare Homer, Jarrod J. Langendijk, Johannes A. Lee, Lip Wai Lester, James Lowe, Matthew McPartlin, Andrew Miles, Elizabeth Nutting, Christopher Palaniappan, Nachi Prestwich, Robin Price, James M. Roberts, Clare Roe, Justin Shanmugasundaram, Ramkumar Simões, Rita Thompson, Anna West, Catharine Wilson, Lorna Wolstenholme, Jane Hall, Emma |
| author_sort | Thomson, David J. |
| collection | PubMed |
| description | • There is a lack of prospective level I evidence for the use of PBT for most adult cancers including oropharyngeal squamous cell carcinoma (OPSCC). • TORPEdO is the UK’s first PBT clinical trial and aims to determine the benefits of PBT for OPSCC. • Training and support has been provided before and during the trial to reduce variations of contouring and radiotherapy planning. • There is a strong translational component within TORPEdO. Imaging and physics data along with blood, tissue collection will inform future studies in refining patient selection for IMPT. |
| format | Online Article Text |
| id | pubmed-9702982 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-97029822022-11-29 TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer Thomson, David J. Cruickshank, Clare Baines, Helen Banner, Russell Beasley, Matthew Betts, Guy Bulbeck, Helen Charlwood, Frances Christian, Judith Clarke, Matthew Donnelly, Olly Foran, Bernadette Gillies, Callum Griffin, Clare Homer, Jarrod J. Langendijk, Johannes A. Lee, Lip Wai Lester, James Lowe, Matthew McPartlin, Andrew Miles, Elizabeth Nutting, Christopher Palaniappan, Nachi Prestwich, Robin Price, James M. Roberts, Clare Roe, Justin Shanmugasundaram, Ramkumar Simões, Rita Thompson, Anna West, Catharine Wilson, Lorna Wolstenholme, Jane Hall, Emma Clin Transl Radiat Oncol Article • There is a lack of prospective level I evidence for the use of PBT for most adult cancers including oropharyngeal squamous cell carcinoma (OPSCC). • TORPEdO is the UK’s first PBT clinical trial and aims to determine the benefits of PBT for OPSCC. • Training and support has been provided before and during the trial to reduce variations of contouring and radiotherapy planning. • There is a strong translational component within TORPEdO. Imaging and physics data along with blood, tissue collection will inform future studies in refining patient selection for IMPT. Elsevier 2022-11-21 /pmc/articles/PMC9702982/ /pubmed/36452431 http://dx.doi.org/10.1016/j.ctro.2022.11.010 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Thomson, David J. Cruickshank, Clare Baines, Helen Banner, Russell Beasley, Matthew Betts, Guy Bulbeck, Helen Charlwood, Frances Christian, Judith Clarke, Matthew Donnelly, Olly Foran, Bernadette Gillies, Callum Griffin, Clare Homer, Jarrod J. Langendijk, Johannes A. Lee, Lip Wai Lester, James Lowe, Matthew McPartlin, Andrew Miles, Elizabeth Nutting, Christopher Palaniappan, Nachi Prestwich, Robin Price, James M. Roberts, Clare Roe, Justin Shanmugasundaram, Ramkumar Simões, Rita Thompson, Anna West, Catharine Wilson, Lorna Wolstenholme, Jane Hall, Emma TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer |
| title | TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer |
| title_full | TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer |
| title_fullStr | TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer |
| title_full_unstemmed | TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer |
| title_short | TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer |
| title_sort | torpedo: a phase iii trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9702982/ https://www.ncbi.nlm.nih.gov/pubmed/36452431 http://dx.doi.org/10.1016/j.ctro.2022.11.010 |
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