Characterization of full-length p53 aggregates and their kinetics of formation

Mutations in the TP53 gene are common in cancer with the R248Q missense mutation conferring an increased propensity to aggregate. Previous p53 aggregation studies showed that, at micromolar concentrations, protein unfolding to produce aggregation-prone species is the rate-determining step. Here we s...

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Detalles Bibliográficos
Autores principales: Julian, Linda, Sang, Jason C., Wu, Yunzhao, Meisl, Georg, Brelstaff, Jack H., Miller, Alyssa, Cheetham, Matthew R., Vendruscolo, Michele, Knowles, Tuomas P.J., Ruggeri, Francesco Simone, Bryant, Clare, Ros, Susana, Brindle, Kevin M., Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703098/
https://www.ncbi.nlm.nih.gov/pubmed/36230002
http://dx.doi.org/10.1016/j.bpj.2022.10.013

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