Culture-Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids

BACKGROUND & AIMS: Human intestinal epithelial organoids (IEOs) are a powerful tool to model major aspects of intestinal development, health, and diseases because patient-derived cultures retain many features found in vivo. A necessary aspect of the organoid model is the requirement to expand cu...

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Detalles Bibliográficos
Autores principales: Edgar, Rachel D., Perrone, Francesca, Foster, April R., Payne, Felicity, Lewis, Sophia, Nayak, Komal M., Kraiczy, Judith, Cenier, Aurélie, Torrente, Franco, Salvestrini, Camilla, Heuschkel, Robert, Hensel, Kai O., Harris, Rebecca, Jones, D. Leanne, Zerbino, Daniel R., Zilbauer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703134/
https://www.ncbi.nlm.nih.gov/pubmed/36038072
http://dx.doi.org/10.1016/j.jcmgh.2022.08.008

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