Magnesium homeostasis in deoxygenated sickle erythrocytes is modulated by endothelin‐1 via Na(+)/Mg(2+) exchange

Painful crises in sickle cell disease (SCD) are associated with increased plasma cytokines levels, including endothelin‐1 (ET‐1). Reduced red cell magnesium content, mediated in part by increased Na(+)/Mg(2+) exchanger (NME) activity, contributes to erythrocyte K(+) loss, dehydration and sickling in...

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Detalles Bibliográficos
Autores principales: Romero, José R., Inostroza‐Nieves, Yaritza, Pulido‐Perez, Patricia, Lopez, Pablo, Wohlgemuth, Jay G., Dlott, Jeffrey S., Snyder, L. Michael, Alper, Seth L., Rivera, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703344/
https://www.ncbi.nlm.nih.gov/pubmed/36331552
http://dx.doi.org/10.1096/fj.202201339R

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