Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 expression in rats

BACKGROUND: Trafficking and activation of N-methyl-D-aspartate (NMDA) receptors play an important role in initiating and maintaining postoperative remifentanil-induced hyperalgesia (RIH). Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome has been linked to the development of inflamm...

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Detalles Bibliográficos
Autores principales: Yuan, Yuan, Zhao, Yue, Shen, Mengxi, Wang, Chenxu, Dong, Beibei, Xie, Keliang, Yu, Yang, Yu, Yonghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703502/
https://www.ncbi.nlm.nih.gov/pubmed/35322721
http://dx.doi.org/10.1177/17448069221093016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703502/
https://www.ncbi.nlm.nih.gov/pubmed/35322721
http://dx.doi.org/10.1177/17448069221093016

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