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Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 expression in rats
BACKGROUND: Trafficking and activation of N-methyl-D-aspartate (NMDA) receptors play an important role in initiating and maintaining postoperative remifentanil-induced hyperalgesia (RIH). Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome has been linked to the development of inflamm...
Autores principales: | Yuan, Yuan, Zhao, Yue, Shen, Mengxi, Wang, Chenxu, Dong, Beibei, Xie, Keliang, Yu, Yang, Yu, Yonghao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703502/ https://www.ncbi.nlm.nih.gov/pubmed/35322721 http://dx.doi.org/10.1177/17448069221093016 |
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