IL-6/STAT3 signaling in tumor cells restricts the expression of frameshift-derived neoantigens by SMG1 induction

BACKGROUND: The quality and quantity of tumor neoantigens derived from tumor mutations determines the fate of the immune response in cancer. Frameshift mutations elicit better tumor neoantigens, especially when they are not targeted by nonsense-mediated mRNA decay (NMD). For tumor progression, malig...

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Detalles Bibliográficos
Autores principales: Meraviglia-Crivelli, Daniel, Villanueva, Helena, Zheleva, Angelina, Villalba-Esparza, María, Moreno, Beatriz, Menon, Ashwathi Puravankara, Calvo, Alfonso, Cebollero, Javier, Barainka, Martin, de los Mozos, Igor Ruiz, Huesa-Berral, Carlos, Pastor, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703761/
https://www.ncbi.nlm.nih.gov/pubmed/36443756
http://dx.doi.org/10.1186/s12943-022-01679-6

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