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Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition

BACKGROUND: Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant tumor characterized by an intensive desmoplastic reaction due to the exaggerated presence of the extracellular (ECM) matrix components. Liver fibroblasts close to the tumor, activated by transforming growth factor (TGF)-β1 and...

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Detalles Bibliográficos
Autores principales:	Mancarella, Serena, Gigante, Isabella, Serino, Grazia, Pizzuto, Elena, Dituri, Francesco, Valentini, Maria F., Wang, Jingxiao, Chen, Xin, Armentano, Raffaele, Calvisi, Diego F., Giannelli, Gianluigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703776/ https://www.ncbi.nlm.nih.gov/pubmed/36443822 http://dx.doi.org/10.1186/s13046-022-02536-6

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