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Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit
BACKGROUND: We wanted to demonstrate whether the initial platelet-to-albumin ratio (PAR) had predictive value for cardiac surgery-associated acute kidney injury (CSA-AKI) and prognosis of critical care patients. METHODS: This is an observational and multi-center study from the MIMIC-IV database, the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704005/ https://www.ncbi.nlm.nih.gov/pubmed/36451801 http://dx.doi.org/10.2147/IJGM.S389846 |
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author | He, Zhenshuo Wang, Haizhi Wang, Shan Li, Lu |
author_facet | He, Zhenshuo Wang, Haizhi Wang, Shan Li, Lu |
author_sort | He, Zhenshuo |
collection | PubMed |
description | BACKGROUND: We wanted to demonstrate whether the initial platelet-to-albumin ratio (PAR) had predictive value for cardiac surgery-associated acute kidney injury (CSA-AKI) and prognosis of critical care patients. METHODS: This is an observational and multi-center study from the MIMIC-IV database, the eICU-CRD database as well as CS patients at our institution. Logistic regression and Cox regression analyses were applied to determine the predictive value for CSA-AKI and in-hospital mortality. LASSO and SVM-RFE models were then employed to discover the coincident variables connected with CSA-AKI. The main objective of this research was the incidence of CSA-AKI, whereas the secondary endpoint was in-hospital death. RESULTS: The higher PAR value (≥4.67) had a higher risk of CSA-AKI (adjusted OR = 4.02, 95% CI 3.41–4.75, P < 0.001) and in-hospital mortality (HR = 2.41 95% CI 1.44–4.03, P = 0.001) after adjusted for other confounding factors including patients with or without chronic kidney disease. The proposed nomogram based on PAR and others clinical factors selected by LASSO and SVM-RFE models for CSA-AKI had the C-index 0.821 (95% CI 0.807–0.834), 0.808 (95% CI 0.787–0.829), 0.745 (95% CI 0.728–0.762), and 0.826 (95% CI 0.753–0.899) in these cohorts, respectively. The nomogram exhibited both remarkable calibration capacity and therapeutic helpfulness in all groups. CONCLUSION: PAR is a relative excellent measure for the event AKI and prognosis of ICU patients who undergone CS. The suggested nomogram based on PAR resulted in an accurate prediction for the detection of critical care patients with CSA-AKI. |
format | Online Article Text |
id | pubmed-9704005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-97040052022-11-29 Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit He, Zhenshuo Wang, Haizhi Wang, Shan Li, Lu Int J Gen Med Original Research BACKGROUND: We wanted to demonstrate whether the initial platelet-to-albumin ratio (PAR) had predictive value for cardiac surgery-associated acute kidney injury (CSA-AKI) and prognosis of critical care patients. METHODS: This is an observational and multi-center study from the MIMIC-IV database, the eICU-CRD database as well as CS patients at our institution. Logistic regression and Cox regression analyses were applied to determine the predictive value for CSA-AKI and in-hospital mortality. LASSO and SVM-RFE models were then employed to discover the coincident variables connected with CSA-AKI. The main objective of this research was the incidence of CSA-AKI, whereas the secondary endpoint was in-hospital death. RESULTS: The higher PAR value (≥4.67) had a higher risk of CSA-AKI (adjusted OR = 4.02, 95% CI 3.41–4.75, P < 0.001) and in-hospital mortality (HR = 2.41 95% CI 1.44–4.03, P = 0.001) after adjusted for other confounding factors including patients with or without chronic kidney disease. The proposed nomogram based on PAR and others clinical factors selected by LASSO and SVM-RFE models for CSA-AKI had the C-index 0.821 (95% CI 0.807–0.834), 0.808 (95% CI 0.787–0.829), 0.745 (95% CI 0.728–0.762), and 0.826 (95% CI 0.753–0.899) in these cohorts, respectively. The nomogram exhibited both remarkable calibration capacity and therapeutic helpfulness in all groups. CONCLUSION: PAR is a relative excellent measure for the event AKI and prognosis of ICU patients who undergone CS. The suggested nomogram based on PAR resulted in an accurate prediction for the detection of critical care patients with CSA-AKI. Dove 2022-11-24 /pmc/articles/PMC9704005/ /pubmed/36451801 http://dx.doi.org/10.2147/IJGM.S389846 Text en © 2022 He et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research He, Zhenshuo Wang, Haizhi Wang, Shan Li, Lu Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit |
title | Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit |
title_full | Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit |
title_fullStr | Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit |
title_full_unstemmed | Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit |
title_short | Predictive Value of Platelet-to-Albumin Ratio (PAR) for the Cardiac-Associated Acute Kidney Injury and Prognosis of Patients in the Intensive Care Unit |
title_sort | predictive value of platelet-to-albumin ratio (par) for the cardiac-associated acute kidney injury and prognosis of patients in the intensive care unit |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704005/ https://www.ncbi.nlm.nih.gov/pubmed/36451801 http://dx.doi.org/10.2147/IJGM.S389846 |
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