Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors

New thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC(50 )= 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib (IC(50 )= 0.045 µM) with high SI (316, 268, 204, an...

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Detalles Bibliográficos
Autores principales: El-Miligy, Mostafa M. M., Al-Kubeisi, Ahmed K., Bekhit, Mohamed G., El-Zemity, Saad R., Nassra, Rasha A., Hazzaa, Aly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704104/
https://www.ncbi.nlm.nih.gov/pubmed/36408833
http://dx.doi.org/10.1080/14756366.2022.2147164

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