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A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers
The propensity for some monoclonal antibodies (mAbs) to aggregate at physiological and manufacturing pH values can prevent their use as therapeutic molecules or delay time to market. Consequently, developability assessments are essential to select optimum candidates, or inform on mitigation strategi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704409/ https://www.ncbi.nlm.nih.gov/pubmed/36418193 http://dx.doi.org/10.1080/19420862.2022.2138092 |