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Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials

BACKGROUND: Additional therapeutic strategies could benefit efforts to reverse the recent increase in malaria cases in sub-Saharan Africa, which mostly affects young children. A primary candidate is dihydroartemisinin + piperaquine (DHA + PPQ), which is effective for uncomplicated malaria treatment,...

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Detalles Bibliográficos
Autores principales:	Wicht, Kathryn J, Small-Saunders, Jennifer L, Hagenah, Laura M, Mok, Sachel, Fidock, David A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Major Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704436/ https://www.ncbi.nlm.nih.gov/pubmed/36082431 http://dx.doi.org/10.1093/infdis/jiac365

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