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Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study

INTRODUCTION: Morphea (localized scleroderma) is a rare, chronic, inflammatory connective tissue disease, characterized by immune system dysfunction, vasculopathy and skin fibrosis. One of the most effective treatments is phototherapy. Phototherapy has been found to be effective in treating localize...

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Autores principales: Malewska-Woźniak, Anna, Lodyga, Martha, Adamski, Zygmunt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704460/
https://www.ncbi.nlm.nih.gov/pubmed/36457686
http://dx.doi.org/10.5114/ada.2021.113127
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author Malewska-Woźniak, Anna
Lodyga, Martha
Adamski, Zygmunt
author_facet Malewska-Woźniak, Anna
Lodyga, Martha
Adamski, Zygmunt
author_sort Malewska-Woźniak, Anna
collection PubMed
description INTRODUCTION: Morphea (localized scleroderma) is a rare, chronic, inflammatory connective tissue disease, characterized by immune system dysfunction, vasculopathy and skin fibrosis. One of the most effective treatments is phototherapy. Phototherapy has been found to be effective in treating localized scleroderma by inducing the expression of metalloproteinase-1. AIM: To compare the concentrations of metalloproteinase (MMP-1) before psoralen and ultraviolet A (PUVA) and ultraviolet A1 (UVA1) treatments in the serum of patients with morphea. MATERIAL AND METHODS: The observational study was conducted in one research centre and included patients with generalised morphea who were treated with PUVA and UVA1 phototherapies. The mean age of all morphea patients included in the study was 55.7 years. The levels of MMP-1 were examined by ELISA (The Biorbyt Human MMP-1 ELISA – Enzyme-Linked Immunosorbent Assay). RESULTS: The study showed that patients treated with PUVA and UVA1 had an improvement based on clinical measures, resulting in a reduction of clinical score. However, we did not observe statistically significant differences in MMP-1 concentrations before and after treatment. Limitations: The study sample was relatively small. Further studies on a larger group of patients would be beneficial. CONCLUSIONS: Our data suggest that there is a possible correlation between MMP-1 concentrations and phototherapy. MMP-1 levels were found to be increased following phototherapy treatment, which may suggest a correlation with better response to treatment in patients with morphea. However, further research is needed.
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spelling pubmed-97044602022-11-30 Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study Malewska-Woźniak, Anna Lodyga, Martha Adamski, Zygmunt Postepy Dermatol Alergol Original Paper INTRODUCTION: Morphea (localized scleroderma) is a rare, chronic, inflammatory connective tissue disease, characterized by immune system dysfunction, vasculopathy and skin fibrosis. One of the most effective treatments is phototherapy. Phototherapy has been found to be effective in treating localized scleroderma by inducing the expression of metalloproteinase-1. AIM: To compare the concentrations of metalloproteinase (MMP-1) before psoralen and ultraviolet A (PUVA) and ultraviolet A1 (UVA1) treatments in the serum of patients with morphea. MATERIAL AND METHODS: The observational study was conducted in one research centre and included patients with generalised morphea who were treated with PUVA and UVA1 phototherapies. The mean age of all morphea patients included in the study was 55.7 years. The levels of MMP-1 were examined by ELISA (The Biorbyt Human MMP-1 ELISA – Enzyme-Linked Immunosorbent Assay). RESULTS: The study showed that patients treated with PUVA and UVA1 had an improvement based on clinical measures, resulting in a reduction of clinical score. However, we did not observe statistically significant differences in MMP-1 concentrations before and after treatment. Limitations: The study sample was relatively small. Further studies on a larger group of patients would be beneficial. CONCLUSIONS: Our data suggest that there is a possible correlation between MMP-1 concentrations and phototherapy. MMP-1 levels were found to be increased following phototherapy treatment, which may suggest a correlation with better response to treatment in patients with morphea. However, further research is needed. Termedia Publishing House 2022-02-04 2022-10 /pmc/articles/PMC9704460/ /pubmed/36457686 http://dx.doi.org/10.5114/ada.2021.113127 Text en Copyright: © 2022 Termedia Sp. z o. o. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Malewska-Woźniak, Anna
Lodyga, Martha
Adamski, Zygmunt
Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study
title Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study
title_full Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study
title_fullStr Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study
title_full_unstemmed Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study
title_short Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study
title_sort concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704460/
https://www.ncbi.nlm.nih.gov/pubmed/36457686
http://dx.doi.org/10.5114/ada.2021.113127
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