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Dynamics of phagocytosis mediated by phosphatidylserine

Phagocytosis triggered by the phospholipid phosphatidylserine (PS) is key for the removal of apoptotic cells in development, tissue homeostasis and infection. Modulation of PS-mediated phagocytosis is an attractive target for therapeutic intervention in the context of atherosclerosis, neurodegenerat...

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Autor principal: Vorselen, Daan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704538/
https://www.ncbi.nlm.nih.gov/pubmed/36281986
http://dx.doi.org/10.1042/BST20211254
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author Vorselen, Daan
author_facet Vorselen, Daan
author_sort Vorselen, Daan
collection PubMed
description Phagocytosis triggered by the phospholipid phosphatidylserine (PS) is key for the removal of apoptotic cells in development, tissue homeostasis and infection. Modulation of PS-mediated phagocytosis is an attractive target for therapeutic intervention in the context of atherosclerosis, neurodegenerative disease, and cancer. Whereas the mechanisms of target recognition, lipid and protein signalling, and cytoskeletal remodelling in opsonin-driven modes of phagocytosis are increasingly well understood, PS-mediated phagocytosis has remained more elusive. This is partially due to the involvement of a multitude of receptors with at least some redundancy in functioning, which complicates dissecting their contributions and results in complex downstream signalling networks. This review focusses on the receptors involved in PS-recognition, the signalling cascades that connect receptors to cytoskeletal remodelling required for phagocytosis, and recent progress in our understanding of how phagocytic cup formation is coordinated during PS-mediated phagocytosis.
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spelling pubmed-97045382022-12-06 Dynamics of phagocytosis mediated by phosphatidylserine Vorselen, Daan Biochem Soc Trans Review Articles Phagocytosis triggered by the phospholipid phosphatidylserine (PS) is key for the removal of apoptotic cells in development, tissue homeostasis and infection. Modulation of PS-mediated phagocytosis is an attractive target for therapeutic intervention in the context of atherosclerosis, neurodegenerative disease, and cancer. Whereas the mechanisms of target recognition, lipid and protein signalling, and cytoskeletal remodelling in opsonin-driven modes of phagocytosis are increasingly well understood, PS-mediated phagocytosis has remained more elusive. This is partially due to the involvement of a multitude of receptors with at least some redundancy in functioning, which complicates dissecting their contributions and results in complex downstream signalling networks. This review focusses on the receptors involved in PS-recognition, the signalling cascades that connect receptors to cytoskeletal remodelling required for phagocytosis, and recent progress in our understanding of how phagocytic cup formation is coordinated during PS-mediated phagocytosis. Portland Press Ltd. 2022-10-31 2022-10-25 /pmc/articles/PMC9704538/ /pubmed/36281986 http://dx.doi.org/10.1042/BST20211254 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Vorselen, Daan
Dynamics of phagocytosis mediated by phosphatidylserine
title Dynamics of phagocytosis mediated by phosphatidylserine
title_full Dynamics of phagocytosis mediated by phosphatidylserine
title_fullStr Dynamics of phagocytosis mediated by phosphatidylserine
title_full_unstemmed Dynamics of phagocytosis mediated by phosphatidylserine
title_short Dynamics of phagocytosis mediated by phosphatidylserine
title_sort dynamics of phagocytosis mediated by phosphatidylserine
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704538/
https://www.ncbi.nlm.nih.gov/pubmed/36281986
http://dx.doi.org/10.1042/BST20211254
work_keys_str_mv AT vorselendaan dynamicsofphagocytosismediatedbyphosphatidylserine