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Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains
Cerebral organoids show great promise as tools to unravel the complex mechanisms by which the mammalian brain develops during embryogenesis. We generated mouse cerebral organoids harbouring constitutive or conditional mutations in Pax6, which encodes a transcription factor with multiple important ro...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704552/ https://www.ncbi.nlm.nih.gov/pubmed/36441708 http://dx.doi.org/10.1371/journal.pone.0278147 |