Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes

Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to the phenotypes observed in aging and telomere biology disorders. One candidate is RAP1, a telomere-associated protein...

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Detalles Bibliográficos
Autores principales: Stock, Amanda J., McDevitt, Ross A., Puligilla, Chandrakala, Wang, Yajun, Zhang, Yongqing, Wang, Kun, Sun, Chongkui, Becker, Kevin G., Lehrmann, Elin, Wood, William H., Gong, Yi, Aqdas, Mohammad, Sung, Myong-Hee, Hoffmann, Victoria, Liu, Chengyu, Gorospe, Myriam, Harrington, Lea, Ferrucci, Luigi, Liu, Yie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704629/
https://www.ncbi.nlm.nih.gov/pubmed/36441670
http://dx.doi.org/10.1371/journal.pgen.1010506

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