_version_ 1784840096476823552
author Hunter, Jill E.
Campbell, Amy E.
Butterworth, Jacqueline A.
Sellier, Helene
Hannaway, Nicola L.
Luli, Saimir
Floudas, Achilleas
Kenneth, Niall S.
Moore, Adam J.
Brownridge, Philip J.
Thomas, Huw D.
Coxhead, Jonathan
Taylor, Leigh
Leary, Peter
Hasoon, Megan S.R.
Knight, Andrew M.
Garrett, Michelle D.
Collins, Ian
Eyers, Claire E.
Perkins, Neil D.
author_facet Hunter, Jill E.
Campbell, Amy E.
Butterworth, Jacqueline A.
Sellier, Helene
Hannaway, Nicola L.
Luli, Saimir
Floudas, Achilleas
Kenneth, Niall S.
Moore, Adam J.
Brownridge, Philip J.
Thomas, Huw D.
Coxhead, Jonathan
Taylor, Leigh
Leary, Peter
Hasoon, Megan S.R.
Knight, Andrew M.
Garrett, Michelle D.
Collins, Ian
Eyers, Claire E.
Perkins, Neil D.
author_sort Hunter, Jill E.
collection PubMed
description
format Online
Article
Text
id pubmed-9704643
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-97046432022-12-06 Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance Hunter, Jill E. Campbell, Amy E. Butterworth, Jacqueline A. Sellier, Helene Hannaway, Nicola L. Luli, Saimir Floudas, Achilleas Kenneth, Niall S. Moore, Adam J. Brownridge, Philip J. Thomas, Huw D. Coxhead, Jonathan Taylor, Leigh Leary, Peter Hasoon, Megan S.R. Knight, Andrew M. Garrett, Michelle D. Collins, Ian Eyers, Claire E. Perkins, Neil D. Biochem J Cancer Portland Press Ltd. 2022-10-14 /pmc/articles/PMC9704643/ /pubmed/36240065 http://dx.doi.org/10.1042/BCJ20220089 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University of Liverpool in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC.
spellingShingle Cancer
Hunter, Jill E.
Campbell, Amy E.
Butterworth, Jacqueline A.
Sellier, Helene
Hannaway, Nicola L.
Luli, Saimir
Floudas, Achilleas
Kenneth, Niall S.
Moore, Adam J.
Brownridge, Philip J.
Thomas, Huw D.
Coxhead, Jonathan
Taylor, Leigh
Leary, Peter
Hasoon, Megan S.R.
Knight, Andrew M.
Garrett, Michelle D.
Collins, Ian
Eyers, Claire E.
Perkins, Neil D.
Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
title Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
title_full Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
title_fullStr Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
title_full_unstemmed Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
title_short Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
title_sort mutation of the rela(p65) thr505 phosphosite disrupts the dna replication stress response leading to chk1 inhibitor resistance
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704643/
https://www.ncbi.nlm.nih.gov/pubmed/36240065
http://dx.doi.org/10.1042/BCJ20220089
work_keys_str_mv AT hunterjille mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT campbellamye mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT butterworthjacquelinea mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT sellierhelene mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT hannawaynicolal mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT lulisaimir mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT floudasachilleas mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT kennethnialls mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT mooreadamj mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT brownridgephilipj mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT thomashuwd mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT coxheadjonathan mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT taylorleigh mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT learypeter mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT hasoonmegansr mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT knightandrewm mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT garrettmichelled mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT collinsian mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT eyersclairee mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance
AT perkinsneild mutationoftherelap65thr505phosphositedisruptsthednareplicationstressresponseleadingtochk1inhibitorresistance