Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

The development of resistance and the activation of bypass pathway signalling represents a major problem for the clinical application of protein kinase inhibitors. While investigating the effect of either a c-Rel deletion or RelA(T505A) phosphosite knockin on the Eµ-Myc mouse model of B-cell lymphom...

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Detalles Bibliográficos
Autores principales: Hunter, Jill E., Campbell, Amy E., Kerridge, Scott, Fraser, Callum, Hannaway, Nicola L., Luli, Saimir, Ivanova, Iglika, Brownridge, Philip J., Coxhead, Jonathan, Taylor, Leigh, Leary, Peter, Hasoon, Megan S. R., Eyers, Claire E., Perkins, Neil D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704644/
https://www.ncbi.nlm.nih.gov/pubmed/36240067
http://dx.doi.org/10.1042/BCJ20220103

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