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Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial

BACKGROUND: Treatment failure and disease relapse among tuberculosis (TB) patients are commonly caused by non-adherence. It can lead to prolonged infection, increased transmission, drug resistance, and loss of life. Even though the causative microorganism of TB has been identified for more than a ce...

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Autores principales: Khamis, Khalda Mohamed, Kadir Shahar, Hayati, Abdul Manaf, Rosliza, Hamdan, Hamdan Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704653/
https://www.ncbi.nlm.nih.gov/pubmed/36441678
http://dx.doi.org/10.1371/journal.pone.0277888
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author Khamis, Khalda Mohamed
Kadir Shahar, Hayati
Abdul Manaf, Rosliza
Hamdan, Hamdan Mustafa
author_facet Khamis, Khalda Mohamed
Kadir Shahar, Hayati
Abdul Manaf, Rosliza
Hamdan, Hamdan Mustafa
author_sort Khamis, Khalda Mohamed
collection PubMed
description BACKGROUND: Treatment failure and disease relapse among tuberculosis (TB) patients are commonly caused by non-adherence. It can lead to prolonged infection, increased transmission, drug resistance, and loss of life. Even though the causative microorganism of TB has been identified for more than a century, the disease is still a substantial public health problem worldwide. This research aims to devise, implement, and assess an educational intervention to improve adherence to TB treatment. METHODS AND FINDINGS: A randomised clinical trial involving 146 Sudanese TB patients will be conducted at the Abu Anga hospital in Khartoum. The participants will be randomly assigned to the intervention and control groups. A 2-hour session will be offered to the intervention group in a one-day TB educational intervention course. The same educational materials will also be provided to the control group after the randomised controlled trial (RCT). Data will be collected at baseline, one month, and four months after the intervention. The primary outcome of interest is TB treatment adherence, while secondary outcomes include quality of life score, tuberculosis knowledge, and health belief domains. Generalised estimating equations (GEE) in SPSS software version 25.0 will be utilised to evaluate the changes over time. CONCLUSIONS: This trial will provide information that could be used in improving TB control strategies to achieve better results in the adherence of healthcare services to the norms of the National Program and patient adherence to the disease treatment and cure. TRIAL REGISTRATION: This study is registered at TCTR: (TCTR20210607006).
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spelling pubmed-97046532022-11-29 Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial Khamis, Khalda Mohamed Kadir Shahar, Hayati Abdul Manaf, Rosliza Hamdan, Hamdan Mustafa PLoS One Study Protocol BACKGROUND: Treatment failure and disease relapse among tuberculosis (TB) patients are commonly caused by non-adherence. It can lead to prolonged infection, increased transmission, drug resistance, and loss of life. Even though the causative microorganism of TB has been identified for more than a century, the disease is still a substantial public health problem worldwide. This research aims to devise, implement, and assess an educational intervention to improve adherence to TB treatment. METHODS AND FINDINGS: A randomised clinical trial involving 146 Sudanese TB patients will be conducted at the Abu Anga hospital in Khartoum. The participants will be randomly assigned to the intervention and control groups. A 2-hour session will be offered to the intervention group in a one-day TB educational intervention course. The same educational materials will also be provided to the control group after the randomised controlled trial (RCT). Data will be collected at baseline, one month, and four months after the intervention. The primary outcome of interest is TB treatment adherence, while secondary outcomes include quality of life score, tuberculosis knowledge, and health belief domains. Generalised estimating equations (GEE) in SPSS software version 25.0 will be utilised to evaluate the changes over time. CONCLUSIONS: This trial will provide information that could be used in improving TB control strategies to achieve better results in the adherence of healthcare services to the norms of the National Program and patient adherence to the disease treatment and cure. TRIAL REGISTRATION: This study is registered at TCTR: (TCTR20210607006). Public Library of Science 2022-11-28 /pmc/articles/PMC9704653/ /pubmed/36441678 http://dx.doi.org/10.1371/journal.pone.0277888 Text en © 2022 Khamis et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Study Protocol
Khamis, Khalda Mohamed
Kadir Shahar, Hayati
Abdul Manaf, Rosliza
Hamdan, Hamdan Mustafa
Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial
title Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial
title_full Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial
title_fullStr Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial
title_full_unstemmed Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial
title_short Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial
title_sort effectiveness of education intervention of tuberculosis treatment adherence in khartoum state: a study protocol for a randomized control trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704653/
https://www.ncbi.nlm.nih.gov/pubmed/36441678
http://dx.doi.org/10.1371/journal.pone.0277888
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