Myeloid Ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver

BACKGROUND & AIMS: Although Ikaros (IKZF1) is a well-established transcriptional regulator in leukocyte lymphopoiesis and differentiation, its role in myeloid innate immune responses remains unclear. Sirtuin 1 (SIRT1) is a histone/protein deacetylase involved in cellular senescence, inflammation...

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Detalles Bibliográficos
Autores principales: Kadono, Kentaro, Kageyama, Shoichi, Nakamura, Kojiro, Hirao, Hirofumi, Ito, Takahiro, Kojima, Hidenobu, Dery, Kenneth J., Li, Xiaoling, Kupiec-Weglinski, Jerzy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704689/
https://www.ncbi.nlm.nih.gov/pubmed/34871625
http://dx.doi.org/10.1016/j.jhep.2021.11.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704689/
https://www.ncbi.nlm.nih.gov/pubmed/34871625
http://dx.doi.org/10.1016/j.jhep.2021.11.026

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