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PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53

Senescence in pancreatic beta cells plays a major role in beta cell dysfunction, which leads to impaired glucose homeostasis and diabetes. Therefore, prevention of beta cell senescence could reduce the risk of diabetes. Treatment of nonobese diabetic (NOD) mice, a model of type 1 autoimmune diabetes...

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Detalles Bibliográficos
Autores principales:	Rubin de Celis, Maria F., Garcia-Martin, Ruben, Syed, Ismail, Lee, Jennifer, Aguayo-Mazzucato, Cristina, Bonner-Weir, Susan, Kahn, Barbara B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704710/ https://www.ncbi.nlm.nih.gov/pubmed/36375063 http://dx.doi.org/10.1073/pnas.2206923119

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