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Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry

RNA-binding proteins contain intrinsically disordered regions whose functions in RNA recognition are poorly understood. The RNA chaperone Hfq is a homohexamer that contains six flexible C-terminal domains (CTDs). The effect of the CTDs on Hfq’s integrity and RNA binding has been challenging to study...

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Detalles Bibliográficos
Autores principales:	Sarni, Samantha H., Roca, Jorjethe, Du, Chen, Jia, Mengxuan, Li, Hantian, Damjanovic, Ana, Małecka, Ewelina M., Wysocki, Vicki H., Woodson, Sarah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704730/ https://www.ncbi.nlm.nih.gov/pubmed/36375072 http://dx.doi.org/10.1073/pnas.2208780119

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