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Interrelating differences in structural and functional connectivity in the older adult's brain

In the normal aging process, the functional connectome restructures and shows a shift from more segregated to more integrated brain networks, which manifests itself in highly different cognitive performances in older adults. Underpinnings of this reorganization are not fully understood, but may be r...

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Autores principales: Stumme, Johanna, Krämer, Camilla, Miller, Tatiana, Schreiber, Jan, Caspers, Svenja, Jockwitz, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704795/
https://www.ncbi.nlm.nih.gov/pubmed/35916531
http://dx.doi.org/10.1002/hbm.26030
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author Stumme, Johanna
Krämer, Camilla
Miller, Tatiana
Schreiber, Jan
Caspers, Svenja
Jockwitz, Christiane
author_facet Stumme, Johanna
Krämer, Camilla
Miller, Tatiana
Schreiber, Jan
Caspers, Svenja
Jockwitz, Christiane
author_sort Stumme, Johanna
collection PubMed
description In the normal aging process, the functional connectome restructures and shows a shift from more segregated to more integrated brain networks, which manifests itself in highly different cognitive performances in older adults. Underpinnings of this reorganization are not fully understood, but may be related to age‐related differences in structural connectivity, the underlying scaffold for information exchange between regions. The structure–function relationship might be a promising factor to understand the neurobiological sources of interindividual cognitive variability, but remain unclear in older adults. Here, we used diffusion weighted and resting‐state functional magnetic resonance imaging as well as cognitive performance data of 573 older subjects from the 1000BRAINS cohort (55–85 years, 287 males) and performed a partial least square regression on 400 regional functional and structural connectivity (FC and SC, respectively) estimates comprising seven resting‐state networks. Our aim was to identify FC and SC patterns that are, together with cognitive performance, characteristic of the older adults aging process. Results revealed three different aging profiles prevalent in older adults. FC was found to behave differently depending on the severity of age‐related SC deteriorations. A functionally highly interconnected system is associated with a structural connectome that shows only minor age‐related decreases. Because this connectivity profile was associated with the most severe age‐related cognitive decline, a more interconnected FC system in older adults points to a process of dedifferentiation. Thus, functional network integration appears to increase primarily when SC begins to decline, but this does not appear to mitigate the decline in cognitive performance.
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spelling pubmed-97047952022-11-29 Interrelating differences in structural and functional connectivity in the older adult's brain Stumme, Johanna Krämer, Camilla Miller, Tatiana Schreiber, Jan Caspers, Svenja Jockwitz, Christiane Hum Brain Mapp Research Articles In the normal aging process, the functional connectome restructures and shows a shift from more segregated to more integrated brain networks, which manifests itself in highly different cognitive performances in older adults. Underpinnings of this reorganization are not fully understood, but may be related to age‐related differences in structural connectivity, the underlying scaffold for information exchange between regions. The structure–function relationship might be a promising factor to understand the neurobiological sources of interindividual cognitive variability, but remain unclear in older adults. Here, we used diffusion weighted and resting‐state functional magnetic resonance imaging as well as cognitive performance data of 573 older subjects from the 1000BRAINS cohort (55–85 years, 287 males) and performed a partial least square regression on 400 regional functional and structural connectivity (FC and SC, respectively) estimates comprising seven resting‐state networks. Our aim was to identify FC and SC patterns that are, together with cognitive performance, characteristic of the older adults aging process. Results revealed three different aging profiles prevalent in older adults. FC was found to behave differently depending on the severity of age‐related SC deteriorations. A functionally highly interconnected system is associated with a structural connectome that shows only minor age‐related decreases. Because this connectivity profile was associated with the most severe age‐related cognitive decline, a more interconnected FC system in older adults points to a process of dedifferentiation. Thus, functional network integration appears to increase primarily when SC begins to decline, but this does not appear to mitigate the decline in cognitive performance. John Wiley & Sons, Inc. 2022-08-02 /pmc/articles/PMC9704795/ /pubmed/35916531 http://dx.doi.org/10.1002/hbm.26030 Text en © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Stumme, Johanna
Krämer, Camilla
Miller, Tatiana
Schreiber, Jan
Caspers, Svenja
Jockwitz, Christiane
Interrelating differences in structural and functional connectivity in the older adult's brain
title Interrelating differences in structural and functional connectivity in the older adult's brain
title_full Interrelating differences in structural and functional connectivity in the older adult's brain
title_fullStr Interrelating differences in structural and functional connectivity in the older adult's brain
title_full_unstemmed Interrelating differences in structural and functional connectivity in the older adult's brain
title_short Interrelating differences in structural and functional connectivity in the older adult's brain
title_sort interrelating differences in structural and functional connectivity in the older adult's brain
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704795/
https://www.ncbi.nlm.nih.gov/pubmed/35916531
http://dx.doi.org/10.1002/hbm.26030
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