Cargando…

Efficacy and safety of abdominal acupuncture in Parkinson’s disease: A protocol for systematic review and meta-analysis

Parkinson disease (PD) is a worldwide spread neurodegenerative disorder. Dopamine replacement therapy is currently the mainstream treatment, which can alleviate the symptoms but induces motor complications. Acupuncture therapy is effective for PD. As a form of acupuncture, the abdominal acupuncture...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Yuehong, Xu, Yilian, Liu, Zhengzhong, Dong, Sihan, Su, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704911/
https://www.ncbi.nlm.nih.gov/pubmed/36451468
http://dx.doi.org/10.1097/MD.0000000000031804
_version_ 1784840162622046208
author Fang, Yuehong
Xu, Yilian
Liu, Zhengzhong
Dong, Sihan
Su, Ying
author_facet Fang, Yuehong
Xu, Yilian
Liu, Zhengzhong
Dong, Sihan
Su, Ying
author_sort Fang, Yuehong
collection PubMed
description Parkinson disease (PD) is a worldwide spread neurodegenerative disorder. Dopamine replacement therapy is currently the mainstream treatment, which can alleviate the symptoms but induces motor complications. Acupuncture therapy is effective for PD. As a form of acupuncture, the abdominal acupuncture has been used to relieve symptoms in patients with PD, but its effectiveness and safety have not yet reached a definitive conclusion. Therefore, this systematic review and meta-analysis protocol is planned to evaluate the efficacy and safety of abdominal acupuncture for PD patients. METHODS: Six English databases (PubMed, Web of Science, MEDLINE, EMBASE, Springer Cochrane Library, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wan Fang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to August 20, 2022. Two reviewers will independently conduct article selection, data collection, and risk of bias evaluation. Any disagreement will be resolved by discussion with the third reviewer. Either the fixed-effects or random-effects model will be used for data synthesis based on the heterogeneity test. Either the fixed-effects or random-effects model will be used for data synthesis based on the heterogeneity test. The analysis will be conducted by RevMan 5.3 software according to Cochrane Handbook. RESULTS: The aim of this systematic review is to provide high-quality evidence to assess the efficacy and safety of abdominal acupuncture for patients in Parkinson’s disease. The efficacy and safety of abdominal acupuncture for PD will be comprehensively assessed from the outcomes, including the effectiveness rate. The Unified Parkinson Disease Rating Scale (UPDRS) and Webster scale, Motor symptom scores utilizing UPDRS III scale, Dopamine (DA) content, and Nonmotor symptom scores employing UPDRS I scale, Activities of daily living using UDPRS II; Complications of treatment applying UPDRS IV, antioxidant ability: super oxide dismutase activity and Lipide Peroxide (LPO) content, Content of inflammatory cytokines, tumor necrosis factor-α and interleukin-1β, and adverse events as the secondary outcome. CONCLUSION: This systematic review will explore whether abdominal acupuncture is an effective and safe intervention for patients in Parkinson’s disease.
format Online
Article
Text
id pubmed-9704911
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-97049112022-11-29 Efficacy and safety of abdominal acupuncture in Parkinson’s disease: A protocol for systematic review and meta-analysis Fang, Yuehong Xu, Yilian Liu, Zhengzhong Dong, Sihan Su, Ying Medicine (Baltimore) 5300 Parkinson disease (PD) is a worldwide spread neurodegenerative disorder. Dopamine replacement therapy is currently the mainstream treatment, which can alleviate the symptoms but induces motor complications. Acupuncture therapy is effective for PD. As a form of acupuncture, the abdominal acupuncture has been used to relieve symptoms in patients with PD, but its effectiveness and safety have not yet reached a definitive conclusion. Therefore, this systematic review and meta-analysis protocol is planned to evaluate the efficacy and safety of abdominal acupuncture for PD patients. METHODS: Six English databases (PubMed, Web of Science, MEDLINE, EMBASE, Springer Cochrane Library, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wan Fang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to August 20, 2022. Two reviewers will independently conduct article selection, data collection, and risk of bias evaluation. Any disagreement will be resolved by discussion with the third reviewer. Either the fixed-effects or random-effects model will be used for data synthesis based on the heterogeneity test. Either the fixed-effects or random-effects model will be used for data synthesis based on the heterogeneity test. The analysis will be conducted by RevMan 5.3 software according to Cochrane Handbook. RESULTS: The aim of this systematic review is to provide high-quality evidence to assess the efficacy and safety of abdominal acupuncture for patients in Parkinson’s disease. The efficacy and safety of abdominal acupuncture for PD will be comprehensively assessed from the outcomes, including the effectiveness rate. The Unified Parkinson Disease Rating Scale (UPDRS) and Webster scale, Motor symptom scores utilizing UPDRS III scale, Dopamine (DA) content, and Nonmotor symptom scores employing UPDRS I scale, Activities of daily living using UDPRS II; Complications of treatment applying UPDRS IV, antioxidant ability: super oxide dismutase activity and Lipide Peroxide (LPO) content, Content of inflammatory cytokines, tumor necrosis factor-α and interleukin-1β, and adverse events as the secondary outcome. CONCLUSION: This systematic review will explore whether abdominal acupuncture is an effective and safe intervention for patients in Parkinson’s disease. Lippincott Williams & Wilkins 2022-11-25 /pmc/articles/PMC9704911/ /pubmed/36451468 http://dx.doi.org/10.1097/MD.0000000000031804 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5300
Fang, Yuehong
Xu, Yilian
Liu, Zhengzhong
Dong, Sihan
Su, Ying
Efficacy and safety of abdominal acupuncture in Parkinson’s disease: A protocol for systematic review and meta-analysis
title Efficacy and safety of abdominal acupuncture in Parkinson’s disease: A protocol for systematic review and meta-analysis
title_full Efficacy and safety of abdominal acupuncture in Parkinson’s disease: A protocol for systematic review and meta-analysis
title_fullStr Efficacy and safety of abdominal acupuncture in Parkinson’s disease: A protocol for systematic review and meta-analysis
title_full_unstemmed Efficacy and safety of abdominal acupuncture in Parkinson’s disease: A protocol for systematic review and meta-analysis
title_short Efficacy and safety of abdominal acupuncture in Parkinson’s disease: A protocol for systematic review and meta-analysis
title_sort efficacy and safety of abdominal acupuncture in parkinson’s disease: a protocol for systematic review and meta-analysis
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704911/
https://www.ncbi.nlm.nih.gov/pubmed/36451468
http://dx.doi.org/10.1097/MD.0000000000031804
work_keys_str_mv AT fangyuehong efficacyandsafetyofabdominalacupunctureinparkinsonsdiseaseaprotocolforsystematicreviewandmetaanalysis
AT xuyilian efficacyandsafetyofabdominalacupunctureinparkinsonsdiseaseaprotocolforsystematicreviewandmetaanalysis
AT liuzhengzhong efficacyandsafetyofabdominalacupunctureinparkinsonsdiseaseaprotocolforsystematicreviewandmetaanalysis
AT dongsihan efficacyandsafetyofabdominalacupunctureinparkinsonsdiseaseaprotocolforsystematicreviewandmetaanalysis
AT suying efficacyandsafetyofabdominalacupunctureinparkinsonsdiseaseaprotocolforsystematicreviewandmetaanalysis