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Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT
Acute myocardial infarction (AMI) is a common cause of death worldwide and heart failure (HF) is the main complication. Although the increase in percutaneous coronary intervention and drug treatment can reduce in-hospital mortality after AMI, the incidence of HF after AMI and the resulting risk of d...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704927/ https://www.ncbi.nlm.nih.gov/pubmed/36451469 http://dx.doi.org/10.1097/MD.0000000000031680 |
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author | Shang, Juju Qiu, Shenglei Zhou, Yingjie Liu, Sina Wang, Zi Lai, Xiaolei Liu, Hongxu Zhou, Mingxue Zhang, Zhenmin Liu, Pengyu Zhang, Fangfang Meng, Xianghui |
author_facet | Shang, Juju Qiu, Shenglei Zhou, Yingjie Liu, Sina Wang, Zi Lai, Xiaolei Liu, Hongxu Zhou, Mingxue Zhang, Zhenmin Liu, Pengyu Zhang, Fangfang Meng, Xianghui |
author_sort | Shang, Juju |
collection | PubMed |
description | Acute myocardial infarction (AMI) is a common cause of death worldwide and heart failure (HF) is the main complication. Although the increase in percutaneous coronary intervention and drug treatment can reduce in-hospital mortality after AMI, the incidence of HF after AMI and the resulting risk of death are still rising, which causes difficulties in the rehabilitation of AMI patients after reperfusion. METHODS: In this prospective, multicenter, randomized, double-blind, double-dummy, placebo-controlled trial, we will assigned 673 eligible patients with AMI after reperfusion into 4 groups: receiving Nao-Xin-Tong capsule (NXT), Bu-Yang-Huan-Wu (BYHW) granule (BYHW), Yang-Yin-Tong-Nao granule (YYTN), or placebo. The course of treatment will be 3 months. The primary outcome is HF incidence within 180 days. Nao-Xin-Tong capsule, BYHW granule, and Yang-Yin-Tong-Nao granule are different traditional Chinese medicines used for tonifying Qi and activating blood (TQAB). RESULTS: Three months of TQAB combined with Western medicine may reduce the incidence of HF after reperfusion of AMI and improve patients’ quality of life. DISCUSSION: This study will provide an important basis for the application of traditional Chinese medicine in patients with AMI after reperfusion and provide an evidence-based basis for the prevention and treatment strategy of HF after AMI. |
format | Online Article Text |
id | pubmed-9704927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-97049272022-11-29 Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT Shang, Juju Qiu, Shenglei Zhou, Yingjie Liu, Sina Wang, Zi Lai, Xiaolei Liu, Hongxu Zhou, Mingxue Zhang, Zhenmin Liu, Pengyu Zhang, Fangfang Meng, Xianghui Medicine (Baltimore) 3400 Acute myocardial infarction (AMI) is a common cause of death worldwide and heart failure (HF) is the main complication. Although the increase in percutaneous coronary intervention and drug treatment can reduce in-hospital mortality after AMI, the incidence of HF after AMI and the resulting risk of death are still rising, which causes difficulties in the rehabilitation of AMI patients after reperfusion. METHODS: In this prospective, multicenter, randomized, double-blind, double-dummy, placebo-controlled trial, we will assigned 673 eligible patients with AMI after reperfusion into 4 groups: receiving Nao-Xin-Tong capsule (NXT), Bu-Yang-Huan-Wu (BYHW) granule (BYHW), Yang-Yin-Tong-Nao granule (YYTN), or placebo. The course of treatment will be 3 months. The primary outcome is HF incidence within 180 days. Nao-Xin-Tong capsule, BYHW granule, and Yang-Yin-Tong-Nao granule are different traditional Chinese medicines used for tonifying Qi and activating blood (TQAB). RESULTS: Three months of TQAB combined with Western medicine may reduce the incidence of HF after reperfusion of AMI and improve patients’ quality of life. DISCUSSION: This study will provide an important basis for the application of traditional Chinese medicine in patients with AMI after reperfusion and provide an evidence-based basis for the prevention and treatment strategy of HF after AMI. Lippincott Williams & Wilkins 2022-11-25 /pmc/articles/PMC9704927/ /pubmed/36451469 http://dx.doi.org/10.1097/MD.0000000000031680 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 3400 Shang, Juju Qiu, Shenglei Zhou, Yingjie Liu, Sina Wang, Zi Lai, Xiaolei Liu, Hongxu Zhou, Mingxue Zhang, Zhenmin Liu, Pengyu Zhang, Fangfang Meng, Xianghui Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT |
title | Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT |
title_full | Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT |
title_fullStr | Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT |
title_full_unstemmed | Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT |
title_short | Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT |
title_sort | efficacy and safety of tonifying qi and activating blood chinese herbal prescriptions for myocardial infarction: study protocol for a multi-centered rct |
topic | 3400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704927/ https://www.ncbi.nlm.nih.gov/pubmed/36451469 http://dx.doi.org/10.1097/MD.0000000000031680 |
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