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Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination
Stroke-like symptoms after COVID-19 vaccination was thought to be functional if there was no anatomical image abnormality. We aimed to analyze brain perfusion changes in these patients. A case-control study of brain perfusion single photon emission computed tomography (SPECT) of 12 vaccinated patien...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704968/ https://www.ncbi.nlm.nih.gov/pubmed/36451484 http://dx.doi.org/10.1097/MD.0000000000031965 |
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author | Tepmongkol, Supatporn Suwanwela, Nijasri C. Hirankarn, Nattiya Tangwongchai, Sookjaroen Vorasayan, Pongpat Sukprakun, Chanan Siritaranon, Natakorn Kijpaisalratana, Naruchorn Akarathanawat, Wasan Chutinet, Aurauma Tantivatana, Jarturon |
author_facet | Tepmongkol, Supatporn Suwanwela, Nijasri C. Hirankarn, Nattiya Tangwongchai, Sookjaroen Vorasayan, Pongpat Sukprakun, Chanan Siritaranon, Natakorn Kijpaisalratana, Naruchorn Akarathanawat, Wasan Chutinet, Aurauma Tantivatana, Jarturon |
author_sort | Tepmongkol, Supatporn |
collection | PubMed |
description | Stroke-like symptoms after COVID-19 vaccination was thought to be functional if there was no anatomical image abnormality. We aimed to analyze brain perfusion changes in these patients. A case-control study of brain perfusion single photon emission computed tomography (SPECT) of 12 vaccinated patients with left-sided stroke-like symptoms were compared with 12 age- and gender-matched normal interictal brain SPECTs using voxel-based analysis. Significant hyperperfusion was seen on the right side in postcentral, inferior parietal, mid temporal, parahippocampal, and caudate regions, and on the left side in the thalamus, hippocampus, and mid temporal areas. In addition, there were hypoperfused bilateral superior frontal gyri and right mid/posterior cingulate cortex (Family-wise-error corrected p-values < .05). Both hypoperfusion and hyperperfusion in the brain are demonstrated. We hypothesize that these findings might be the result of the functional neurological disorder. However, based on other previous studies, circulating spike protein in the patients’ plasma early after vaccination might also be the cause. |
format | Online Article Text |
id | pubmed-9704968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-97049682022-11-29 Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination Tepmongkol, Supatporn Suwanwela, Nijasri C. Hirankarn, Nattiya Tangwongchai, Sookjaroen Vorasayan, Pongpat Sukprakun, Chanan Siritaranon, Natakorn Kijpaisalratana, Naruchorn Akarathanawat, Wasan Chutinet, Aurauma Tantivatana, Jarturon Medicine (Baltimore) 5300 Stroke-like symptoms after COVID-19 vaccination was thought to be functional if there was no anatomical image abnormality. We aimed to analyze brain perfusion changes in these patients. A case-control study of brain perfusion single photon emission computed tomography (SPECT) of 12 vaccinated patients with left-sided stroke-like symptoms were compared with 12 age- and gender-matched normal interictal brain SPECTs using voxel-based analysis. Significant hyperperfusion was seen on the right side in postcentral, inferior parietal, mid temporal, parahippocampal, and caudate regions, and on the left side in the thalamus, hippocampus, and mid temporal areas. In addition, there were hypoperfused bilateral superior frontal gyri and right mid/posterior cingulate cortex (Family-wise-error corrected p-values < .05). Both hypoperfusion and hyperperfusion in the brain are demonstrated. We hypothesize that these findings might be the result of the functional neurological disorder. However, based on other previous studies, circulating spike protein in the patients’ plasma early after vaccination might also be the cause. Lippincott Williams & Wilkins 2022-11-25 /pmc/articles/PMC9704968/ /pubmed/36451484 http://dx.doi.org/10.1097/MD.0000000000031965 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 5300 Tepmongkol, Supatporn Suwanwela, Nijasri C. Hirankarn, Nattiya Tangwongchai, Sookjaroen Vorasayan, Pongpat Sukprakun, Chanan Siritaranon, Natakorn Kijpaisalratana, Naruchorn Akarathanawat, Wasan Chutinet, Aurauma Tantivatana, Jarturon Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination |
title | Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination |
title_full | Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination |
title_fullStr | Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination |
title_full_unstemmed | Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination |
title_short | Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination |
title_sort | brain perfusion single photon emission computed tomography abnormality in mri-negative stroke-like patients post covid-19 vaccination |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704968/ https://www.ncbi.nlm.nih.gov/pubmed/36451484 http://dx.doi.org/10.1097/MD.0000000000031965 |
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