Cargando…

Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination

Stroke-like symptoms after COVID-19 vaccination was thought to be functional if there was no anatomical image abnormality. We aimed to analyze brain perfusion changes in these patients. A case-control study of brain perfusion single photon emission computed tomography (SPECT) of 12 vaccinated patien...

Descripción completa

Detalles Bibliográficos
Autores principales: Tepmongkol, Supatporn, Suwanwela, Nijasri C., Hirankarn, Nattiya, Tangwongchai, Sookjaroen, Vorasayan, Pongpat, Sukprakun, Chanan, Siritaranon, Natakorn, Kijpaisalratana, Naruchorn, Akarathanawat, Wasan, Chutinet, Aurauma, Tantivatana, Jarturon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704968/
https://www.ncbi.nlm.nih.gov/pubmed/36451484
http://dx.doi.org/10.1097/MD.0000000000031965
_version_ 1784840177414307840
author Tepmongkol, Supatporn
Suwanwela, Nijasri C.
Hirankarn, Nattiya
Tangwongchai, Sookjaroen
Vorasayan, Pongpat
Sukprakun, Chanan
Siritaranon, Natakorn
Kijpaisalratana, Naruchorn
Akarathanawat, Wasan
Chutinet, Aurauma
Tantivatana, Jarturon
author_facet Tepmongkol, Supatporn
Suwanwela, Nijasri C.
Hirankarn, Nattiya
Tangwongchai, Sookjaroen
Vorasayan, Pongpat
Sukprakun, Chanan
Siritaranon, Natakorn
Kijpaisalratana, Naruchorn
Akarathanawat, Wasan
Chutinet, Aurauma
Tantivatana, Jarturon
author_sort Tepmongkol, Supatporn
collection PubMed
description Stroke-like symptoms after COVID-19 vaccination was thought to be functional if there was no anatomical image abnormality. We aimed to analyze brain perfusion changes in these patients. A case-control study of brain perfusion single photon emission computed tomography (SPECT) of 12 vaccinated patients with left-sided stroke-like symptoms were compared with 12 age- and gender-matched normal interictal brain SPECTs using voxel-based analysis. Significant hyperperfusion was seen on the right side in postcentral, inferior parietal, mid temporal, parahippocampal, and caudate regions, and on the left side in the thalamus, hippocampus, and mid temporal areas. In addition, there were hypoperfused bilateral superior frontal gyri and right mid/posterior cingulate cortex (Family-wise-error corrected p-values  < .05). Both hypoperfusion and hyperperfusion in the brain are demonstrated. We hypothesize that these findings might be the result of the functional neurological disorder. However, based on other previous studies, circulating spike protein in the patients’ plasma early after vaccination might also be the cause.
format Online
Article
Text
id pubmed-9704968
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-97049682022-11-29 Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination Tepmongkol, Supatporn Suwanwela, Nijasri C. Hirankarn, Nattiya Tangwongchai, Sookjaroen Vorasayan, Pongpat Sukprakun, Chanan Siritaranon, Natakorn Kijpaisalratana, Naruchorn Akarathanawat, Wasan Chutinet, Aurauma Tantivatana, Jarturon Medicine (Baltimore) 5300 Stroke-like symptoms after COVID-19 vaccination was thought to be functional if there was no anatomical image abnormality. We aimed to analyze brain perfusion changes in these patients. A case-control study of brain perfusion single photon emission computed tomography (SPECT) of 12 vaccinated patients with left-sided stroke-like symptoms were compared with 12 age- and gender-matched normal interictal brain SPECTs using voxel-based analysis. Significant hyperperfusion was seen on the right side in postcentral, inferior parietal, mid temporal, parahippocampal, and caudate regions, and on the left side in the thalamus, hippocampus, and mid temporal areas. In addition, there were hypoperfused bilateral superior frontal gyri and right mid/posterior cingulate cortex (Family-wise-error corrected p-values  < .05). Both hypoperfusion and hyperperfusion in the brain are demonstrated. We hypothesize that these findings might be the result of the functional neurological disorder. However, based on other previous studies, circulating spike protein in the patients’ plasma early after vaccination might also be the cause. Lippincott Williams & Wilkins 2022-11-25 /pmc/articles/PMC9704968/ /pubmed/36451484 http://dx.doi.org/10.1097/MD.0000000000031965 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5300
Tepmongkol, Supatporn
Suwanwela, Nijasri C.
Hirankarn, Nattiya
Tangwongchai, Sookjaroen
Vorasayan, Pongpat
Sukprakun, Chanan
Siritaranon, Natakorn
Kijpaisalratana, Naruchorn
Akarathanawat, Wasan
Chutinet, Aurauma
Tantivatana, Jarturon
Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination
title Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination
title_full Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination
title_fullStr Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination
title_full_unstemmed Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination
title_short Brain perfusion single photon emission computed tomography abnormality in MRI-negative stroke-like patients post COVID-19 vaccination
title_sort brain perfusion single photon emission computed tomography abnormality in mri-negative stroke-like patients post covid-19 vaccination
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704968/
https://www.ncbi.nlm.nih.gov/pubmed/36451484
http://dx.doi.org/10.1097/MD.0000000000031965
work_keys_str_mv AT tepmongkolsupatporn brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT suwanwelanijasric brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT hirankarnnattiya brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT tangwongchaisookjaroen brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT vorasayanpongpat brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT sukprakunchanan brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT siritaranonnatakorn brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT kijpaisalratananaruchorn brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT akarathanawatwasan brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT chutinetaurauma brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination
AT tantivatanajarturon brainperfusionsinglephotonemissioncomputedtomographyabnormalityinmrinegativestrokelikepatientspostcovid19vaccination