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Diagnostic test accuracy of PCR by saliva specimen for cytomegalovirus infection in newborn: A protocol for systematic review and meta-analysis
This study aimed to assess the diagnostic accuracy of polymerase-chain-reaction by saliva. METHOD: We searched Pubmed, EMBASE, Cochrane Library and Web of Science. A case–control or cohort study designed to explore the saliva specimens for diagnosing the cytomegalovirus infection was eligible for th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704999/ https://www.ncbi.nlm.nih.gov/pubmed/36451507 http://dx.doi.org/10.1097/MD.0000000000031776 |
Sumario: | This study aimed to assess the diagnostic accuracy of polymerase-chain-reaction by saliva. METHOD: We searched Pubmed, EMBASE, Cochrane Library and Web of Science. A case–control or cohort study designed to explore the saliva specimens for diagnosing the cytomegalovirus infection was eligible for this study. Sensitivity (SEN), specificity (SPE), diagnostic odds ratio (DOR), and summary receiver operating characteristic curves were calculated. RESULTS: Nine articles were selected for the meta-analysis. For assessing saliva PCR with urine culture, the SEN, SPE, and DOR were 0.97 [95% confidential interval (CI):0.61,1.00] 1.00 [95%CI:0.99, 1.00] 15672 [95%CI:558, 440325], respectively; for assessing saliva PCR with urine PCR, the SEN, SPE, and DOR were 0.87 [95%CI:0.79, 0.92] 1.00 [95%CI:1.00, 1.00] 15637 [95%CI:5946, 41126], respectively; for total assessment, the SEN, SPE, and DOR were0.91 [95%CI:0.70, 0.98] 1.00 [95%CI:1.00, 1.00] 8493 [95%CI:1429, 50487], respectively. CONCLUSION: We reported that saliva PCR performed well in the diagnosis of cytomegalovirus infection. |
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