Cargando…

Antitumor Effects of Delta (9)-Tetrahydrocannabinol and Cannabinol on Cholangiocarcinoma Cells and Xenograft Mouse Models

Cholangiocarcinoma (CCA) is a very aggressive tumor. The development of a new therapeutic drug for CCA is required. This study aims to evaluate the antitumor effect of ∆(9)-tetrahydrocannabinol (THC), the major psychoactive component of marijuana (Cannabis sativa), and cannabinol (CBN), a minor, low...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leelawat, Surang, Leelawat, Kawin, Yimsoo, Thunyatorn, Wunnakup, Thaniya, Monton, Chaowalit, Khamthong, Nanthaphong, Madaka, Fameera, Maha, Athip, Songsak, Thanapat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705094/ https://www.ncbi.nlm.nih.gov/pubmed/36452140 http://dx.doi.org/10.1155/2022/6477132

Ejemplares similares

In vitro antioxidant, anti-inflammatory, and anticancer activities of mixture Thai medicinal plants
por: Jongrungraungchok, Suchada, et al.
Publicado: (2023)

Serum NGAL to Clinically Distinguish Cholangiocarcinoma from Benign Biliary Tract Diseases
por: Leelawat, Kawin, et al.
Publicado: (2011)

CD24 induces the invasion of cholangiocarcinoma cells by upregulating CXCR4 and increasing the phosphorylation of ERK1/2
por: LEELAWAT, KAWIN, et al.
Publicado: (2013)

Inhibition of PI3K increases oxaliplatin sensitivity in cholangiocarcinoma cells
por: Leelawat, Kawin, et al.
Publicado: (2009)

Cytokine Secretion of Peripheral Blood Mononuclear Cells by Hydnocarpus anthelminthicus Seeds
por: Leelawat, Surang, et al.
Publicado: (2018)

Investigation of the Interaction of Herbal Ingredients Contained in Triphala Recipe Using Simplex Lattice Design: Chemical Analysis Point of View
por: Monton, Chaowalit, et al.
Publicado: (2020)

Role of mTOR inhibitor in cholangiocarcinoma cell progression
por: MOOLTHIYA, PENPAK, et al.
Publicado: (2014)

Hypoxia enhances cholangiocarcinoma invasion through activation of hepatocyte growth factor receptor and the extracellular signal-regulated kinase signaling pathway
por: VANICHAPOL, THITINEE, et al.
Publicado: (2015)

Effect of Ionic Liquid on Silver-Nanoparticle-Complexed Ganoderma applanatum and Its Topical Film Formulation
por: Maneewattanapinyo, Pattwat, et al.
Publicado: (2023)

Detection of serum MMP-7 and MMP-9 in cholangiocarcinoma patients: evaluation of diagnostic accuracy
por: Leelawat, Kawin, et al.
Publicado: (2009)

Matrigel induces L-plastin expression and promotes L-plastin-dependent invasion in human cholangiocarcinoma cells
por: CHAIJAN, SUTHIDARAK, et al.
Publicado: (2014)

Novel Serum Biomarkers to Differentiate Cholangiocarcinoma from Benign Biliary Tract Diseases Using a Proteomic Approach
por: Janvilisri, Tavan, et al.
Publicado: (2015)

Gadd45β silencing impaired viability and metastatic phenotypes in cholangiocarcinoma cells by modulating the EMT pathway
por: Myint, Kyaw Zwar, et al.
Publicado: (2018)

Evaluation of the White Test for the Intraoperative Detection of Bile Leakage
por: Leelawat, Kawin, et al.
Publicado: (2012)

Proteomic Profiles of Mesenchymal Stem Cells Induced by a Liver Differentiation Protocol
por: Leelawat, Kawin, et al.
Publicado: (2010)

Cannabinol: History, Syntheses, and Biological Profile of the Greatest “Minor” Cannabinoid
por: Maioli, Chiara, et al.
Publicado: (2022)

The effects of subacute exposure to a water-soluble cannabinol compound in male mice
por: Bailey, Melissa M., et al.
Publicado: (2022)

Transcriptome Highlights Cannabinol Modulation of Mitophagy in a Parkinson’s Disease In Vitro Model
por: Gugliandolo, Agnese, et al.
Publicado: (2023)

Secondary Metabolites with Antimicrobial Activities from Chamaecyparis obtusa var. formosana
por: Wu, Ming-Der, et al.
Publicado: (2022)

Correction: Wu et al. Secondary Metabolites with Antimicrobial Activities from Chamaecyparis obtusa var. formosana. Molecules 2022, 27, 429
por: Wu, Ming-Der, et al.
Publicado: (2022)

Effect of Temperature and Duration Time of Maceration on Nitrate Content of Vernonia cinerea (L.) Less.: Circumscribed Central Composite Design and Method Validation
por: Monton, Chaowalit, et al.
Publicado: (2019)

Lysiphyllum strychnifolium (Craib) A. Schmitz Extracts Moderate the Expression of Drug-Metabolizing Enzymes: In Vivo Study to Clinical Propose
por: Kuendee, Natthaporn, et al.
Publicado: (2023)

A Vital Role of High-Pressure Processing in the Gel Forming on New Healthy Egg Pudding through Texture, Microstructure, and Molecular Impacts
por: Ngamlerst, Chattraya, et al.
Publicado: (2022)

Cannabinoid receptor 2 (Cb2r) mediates cannabinol (CBN) induced developmental defects in zebrafish
por: Amin, Md Ruhul, et al.
Publicado: (2022)

Antidote activity and protective effects of Lysiphyllum strychnifolium (Craib) A. Schmitz extract against organophosphate pesticide in omethoate-treated rats
por: Sukprasert, Sophida, et al.
Publicado: (2020)

Validated Reversed-Phase Ion-Interaction High-Performance Liquid Chromatography for Quantitation of Nitrate Content of Clausena anisata (Willd.) Hook. f. ex Benth. Leaves
por: Monton, Chaowalit, et al.
Publicado: (2020)

Identification and quantification of cannabinol as a biomarker for local hemp retting in an ancient sedimentary record by HPTLC-ESI-MS
por: Schmidt, Theresa, et al.
Publicado: (2020)

Acute oral toxicity of damnacanthal and its anticancer activity against colorectal tumorigenesis
por: Woradulayapinij, Warunya, et al.
Publicado: (2022)

Universal health coverage mitigated COVID-19 health-related consequences in Asia Oceania
por: Saengtabtim, Kumpol, et al.
Publicado: (2023)

Quantitation of curcuminoid contents, dissolution profile, and volatile oil content of turmeric capsules produced at some secondary government hospitals
por: Monton, Chaowalit, et al.
Publicado: (2016)

Prevention of Pseudomonas aeruginosa Biofilm Formation on Soft Contact Lenses by Allium sativum Fermented Extract (BGE) and Cannabinol Oil Extract (CBD)
por: Di Onofrio, Valeria, et al.
Publicado: (2019)

Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery
por: Pichayakorn, Wiwat, et al.
Publicado: (2023)

Continuous-Flow Synthesis of Δ(9)-Tetrahydrocannabinol and Δ(8)-Tetrahydrocannabinol from Cannabidiol
por: Bassetti, Benedetta, et al.
Publicado: (2023)

Twitter data sentiment analysis of tourism in Thailand during the COVID-19 pandemic using machine learning
por: Leelawat, Natt, et al.
Publicado: (2022)

Lipid-Lowering and Antioxidative Activities of Aqueous Extracts of Ocimum sanctum L. Leaves in Rats Fed with a High-Cholesterol Diet
por: Suanarunsawat, Thamolwan, et al.
Publicado: (2011)

Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet
por: Suanarunsawat, Thamolwan, et al.
Publicado: (2010)

Tetrahydrocannabinol in Pediatrics: Room for Improvement?
por: de Gier, Charlotte, et al.
Publicado: (2023)

Absence of Relevant Thermal Conversion of Cannabidiol to Tetrahydrocannabinol in E-Cigarette Vapor and Low-Tetrahydrocannabinol Cannabis Smoke
por: Hindelang, Pascal, et al.
Publicado: (2022)

(11)C-Choline and FDG PET/CT Imaging of Primary Cholangiocarcinoma: A Comparative Analysis
por: Chotipanich, Chanisa, et al.
Publicado: (2015)

Delta-8 Tetrahydrocannabinol Product Impurities
por: Ray, Colleen L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_juplq2dp859nihb84missqcjsp