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Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects

Acellular skin as a scaffold has a good potential to regenerate or repair damaged tissues. Growth factors such as Plasma Rich in Growth Factor (PRGF) as a rich source of active proteins can accelerate tissue regeneration. In this study, an acellular scaffold derived from fish skin with growth factor...

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Detalles Bibliográficos
Autores principales: Biazar, Esmaeil, Heidari Keshel, Saeed, Rezaei Tavirani, Mostafa, Kamalvand, Mahshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705163/
https://www.ncbi.nlm.nih.gov/pubmed/35441469
http://dx.doi.org/10.1111/iwj.13821
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author Biazar, Esmaeil
Heidari Keshel, Saeed
Rezaei Tavirani, Mostafa
Kamalvand, Mahshad
author_facet Biazar, Esmaeil
Heidari Keshel, Saeed
Rezaei Tavirani, Mostafa
Kamalvand, Mahshad
author_sort Biazar, Esmaeil
collection PubMed
description Acellular skin as a scaffold has a good potential to regenerate or repair damaged tissues. Growth factors such as Plasma Rich in Growth Factor (PRGF) as a rich source of active proteins can accelerate tissue regeneration. In this study, an acellular scaffold derived from fish skin with growth factors was used to repair full‐thickness skin defects in a rat model. Cellular results demonstrated that epithelial cells adhere well to acellular scaffolds. The results of animal studies showed that the groups treated with acellular scaffold and growth factor have a high ability to close and heal wounds on the 28th day after surgery. Histological and staining results showed that in the treated groups with scaffold and growth factor, an epidermal layer was formed with some skin appendages similar to normal skin. Overall, such scaffolds with biological agents can cause an acceptable synergistic effect on skin regeneration and wound healing.
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spelling pubmed-97051632022-11-29 Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects Biazar, Esmaeil Heidari Keshel, Saeed Rezaei Tavirani, Mostafa Kamalvand, Mahshad Int Wound J Original Articles Acellular skin as a scaffold has a good potential to regenerate or repair damaged tissues. Growth factors such as Plasma Rich in Growth Factor (PRGF) as a rich source of active proteins can accelerate tissue regeneration. In this study, an acellular scaffold derived from fish skin with growth factors was used to repair full‐thickness skin defects in a rat model. Cellular results demonstrated that epithelial cells adhere well to acellular scaffolds. The results of animal studies showed that the groups treated with acellular scaffold and growth factor have a high ability to close and heal wounds on the 28th day after surgery. Histological and staining results showed that in the treated groups with scaffold and growth factor, an epidermal layer was formed with some skin appendages similar to normal skin. Overall, such scaffolds with biological agents can cause an acceptable synergistic effect on skin regeneration and wound healing. Blackwell Publishing Ltd 2022-04-19 /pmc/articles/PMC9705163/ /pubmed/35441469 http://dx.doi.org/10.1111/iwj.13821 Text en © 2022 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Biazar, Esmaeil
Heidari Keshel, Saeed
Rezaei Tavirani, Mostafa
Kamalvand, Mahshad
Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects
title Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects
title_full Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects
title_fullStr Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects
title_full_unstemmed Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects
title_short Healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects
title_sort healing effect of acellular fish skin with plasma rich in growth factor on full‐thickness skin defects
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705163/
https://www.ncbi.nlm.nih.gov/pubmed/35441469
http://dx.doi.org/10.1111/iwj.13821
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